ID   CECB_HYACE              Reviewed;          62 AA.
AC   P01508;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Cecropin-B;
DE   AltName: Full=Immune protein P9;
DE   Flags: Precursor;
OS   Hyalophora cecropia (Cecropia moth) (Samia cecropia).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Attacini; Hyalophora.
OX   NCBI_TaxID=7123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND AMIDATION AT
RP   LEU-61.
RX   PubMed=3857578; DOI=10.1073/pnas.82.8.2240;
RA   van Hofsten P., Faye I., Kockum K., Lee J.-Y., Xanthopoulos K.G.,
RA   Boman I.A., Boman H.G., Engstroem A., Andreu D., Merrifield R.B.;
RT   "Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin B
RT   from Hyalophora cecropia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:2240-2243(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3840100; DOI=10.1016/0145-305x(85)90018-7;
RA   Boman H.G., Faye I., von Hofsten P., Kockum K., Lee J.-Y.,
RA   Xanthopoulos K.G., Bennich H., Engstroem A., Merrifield R.B., Andreu D.;
RT   "On the primary structures of lysozyme, cecropins and attacins from
RT   Hyalophora cecropia.";
RL   Dev. Comp. Immunol. 9:551-558(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3127206; DOI=10.1111/j.1432-1033.1988.tb13896.x;
RA   Xanthopoulos G., Lee J.-Y., Gan R., Kockum K., Faye I., Boman G.;
RT   "The structure of the gene for cecropin B, an antibacterial immune protein
RT   from Hyalophora cecropia.";
RL   Eur. J. Biochem. 172:371-376(1988).
RN   [4]
RP   PROTEIN SEQUENCE OF 27-61.
RX   PubMed=7019715; DOI=10.1038/292246a0;
RA   Steiner H., Hultmark D., Engstroem A., Bennich H., Boman H.G.;
RT   "Sequence and specificity of two antibacterial proteins involved in insect
RT   immunity.";
RL   Nature 292:246-248(1981).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; M10309; AAA29184.1; -; mRNA.
DR   EMBL; M34924; AAA29187.1; -; mRNA.
DR   EMBL; X07404; CAA30306.1; -; Genomic_DNA.
DR   PIR; S02606; CKWKB.
DR   AlphaFoldDB; P01508; -.
DR   SMR; P01508; -.
DR   PRIDE; P01508; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..22
FT   PROPEP          23..26
FT                   /note="Removed by a dipeptidylpeptidase"
FT                   /evidence="ECO:0000269|PubMed:7019715"
FT                   /id="PRO_0000004861"
FT   CHAIN           27..61
FT                   /note="Cecropin-B"
FT                   /id="PRO_0000004862"
FT   MOD_RES         61
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:3857578"
SQ   SEQUENCE   62 AA;  6750 MW;  65E309CB2983BD61 CRC64;
     MNFSRIFFFV FALVLALSTV SAAPEPKWKV FKKIEKMGRN IRNGIVKAGP AIAVLGEAKA
     LG