CECC_ANOGA
ID CECC_ANOGA Reviewed; 59 AA.
AC Q8MUF3; B2FVD8; Q7QEE4;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 4.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Cecropin-C;
DE AltName: Full=AgCecC;
DE Flags: Precursor;
GN Name=CecC; Synonyms=cec2; ORFNames=AGAP000692;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12421409; DOI=10.1046/j.1365-2583.2002.00360.x;
RA Zheng X.-L., Zheng A.L.;
RT "Genomic organization and regulation of three cecropin genes in Anopheles
RT gambiae.";
RL Insect Mol. Biol. 11:517-525(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M1, M2, M3, M4, M5, M6, M7, M8, S1, S2, S3, S4, S5, S6, S7, S8, and
RC S9;
RA Cohuet A., Krishnakumar S., Simard F., Morlais I., Koutsos A.,
RA Fontenille D., Mindrinos M., Kafatos F.C.;
RT "Genetic diversity and adaptive evolution in Anopheles gambiae innate
RT immune system.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC several Gram-positive and Gram-negative bacteria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR EMBL; AF525673; AAM82612.1; -; Genomic_DNA.
DR EMBL; AM774769; CAO83227.1; -; Genomic_DNA.
DR EMBL; AM774770; CAO83228.1; -; Genomic_DNA.
DR EMBL; AM774771; CAO83229.1; -; Genomic_DNA.
DR EMBL; AM774772; CAO83230.1; -; Genomic_DNA.
DR EMBL; AM774773; CAO83231.1; -; Genomic_DNA.
DR EMBL; AM774774; CAO83232.1; -; Genomic_DNA.
DR EMBL; AM774775; CAO83233.1; -; Genomic_DNA.
DR EMBL; AM774776; CAO83234.1; -; Genomic_DNA.
DR EMBL; AM774777; CAO83235.1; -; Genomic_DNA.
DR EMBL; AM774778; CAO83236.1; -; Genomic_DNA.
DR EMBL; AM774779; CAO83237.1; -; Genomic_DNA.
DR EMBL; AM774780; CAO83238.1; -; Genomic_DNA.
DR EMBL; AM774781; CAO83239.1; -; Genomic_DNA.
DR EMBL; AM774782; CAO83240.1; -; Genomic_DNA.
DR EMBL; AM774783; CAO83241.1; -; Genomic_DNA.
DR EMBL; AM774784; CAO83242.1; -; Genomic_DNA.
DR EMBL; AM774785; CAO83243.1; -; Genomic_DNA.
DR EMBL; AAAB01008847; EAA06806.4; -; Genomic_DNA.
DR RefSeq; XP_311222.4; XM_311222.5.
DR AlphaFoldDB; Q8MUF3; -.
DR SMR; Q8MUF3; -.
DR STRING; 7165.AGAP000692-PA; -.
DR PaxDb; Q8MUF3; -.
DR GeneID; 1272277; -.
DR KEGG; aga:AgaP_AGAP000692; -.
DR CTD; 1272277; -.
DR VEuPathDB; VectorBase:AGAP000692; -.
DR eggNOG; ENOG502TB6D; Eukaryota.
DR HOGENOM; CLU_187909_1_1_1; -.
DR InParanoid; Q8MUF3; -.
DR OrthoDB; 1636394at2759; -.
DR PhylomeDB; Q8MUF3; -.
DR Proteomes; UP000007062; Chromosome X.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR000875; Cecropin.
DR InterPro; IPR020400; Cecropin_insect.
DR PANTHER; PTHR38329; PTHR38329; 1.
DR Pfam; PF00272; Cecropin; 1.
PE 3: Inferred from homology;
KW Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..58
FT /note="Cecropin-C"
FT /id="PRO_0000004823"
FT MOD_RES 58
FT /note="Valine amide"
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="Missing (in Ref. 1; AAM82612)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 59 AA; 6302 MW; 77AB884AB24D7A4B CRC64;
MNFKLIFLVA LVLMAAFLGQ TEGRRFKKFL KKVEGAGRRV ANAAQKGLPL AAGVKGLVG
