ID   CECC_DROER              Reviewed;          63 AA.
AC   P84222; Q8WP47;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Cecropin-C;
DE   Flags: Precursor;
GN   Name=CecC;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA   Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT   "Rapid evolution of the male-specific antibacterial protein andropin gene
RT   in Drosophila.";
RL   J. Mol. Evol. 54:665-670(2002).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Expressed during metamorphosis in pupae.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AB047062; BAB78567.1; -; Genomic_DNA.
DR   AlphaFoldDB; P84222; -.
DR   SMR; P84222; -.
DR   STRING; 7220.FBpp0130496; -.
DR   eggNOG; ENOG502TCNK; Eukaryota.
DR   ChiTaRS; CecC; fly.
DR   GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:EnsemblMetazoa.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0002213; P:defense response to insect; IEA:EnsemblMetazoa.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..62
FT                   /note="Cecropin-C"
FT                   /id="PRO_0000004847"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6764 MW;  F8D86507CD727D9C CRC64;
     MNFNKIFVFV ALILAISLGQ SEAGWLKKLG KRIERIGQHT RDATIQGLGI AQQAANVAAT
     ARG