CECC_DROME
ID CECC_DROME Reviewed; 63 AA.
AC O16829; O16830; O16831; O16832; O16833; O16834; O16835; O16836; O16837;
AC P29561; Q9VA89;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Cecropin-C;
DE Flags: Precursor;
GN Name=CecC; ORFNames=CG1373;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S;
RX PubMed=1740152; DOI=10.1111/j.1432-1033.1992.tb16648.x;
RA Tryselius Y., Samakovlis C., Kimbrell D.A., Hultmark D.;
RT "CecC, a cecropin gene expressed during metamorphosis in Drosophila
RT pupae.";
RL Eur. J. Biochem. 204:395-399(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B009, B101, B115, B202, B205, B208, B316, M31, Z10, Z18, Z22, Z24,
RC and Z5;
RX PubMed=9335607; DOI=10.1093/genetics/147.2.713;
RA Clark A.G., Wang L.;
RT "Molecular population genetics of Drosophila immune system genes.";
RL Genetics 147:713-724(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC several Gram-positive and Gram-negative bacteria.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: In the anterior end of the larval hindgut and in
CC other larval tissues that are undergoing histolysis.
CC {ECO:0000269|PubMed:1740152}.
CC -!- DEVELOPMENTAL STAGE: Expressed during metamorphosis in pupae.
CC {ECO:0000269|PubMed:1740152}.
CC -!- INDUCTION: Induced as part of the humoral response to a bacterial
CC invasion. {ECO:0000269|PubMed:1740152}.
CC -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR EMBL; Z11167; CAA77559.1; -; Genomic_DNA.
DR EMBL; AF019007; AAB82504.1; -; Genomic_DNA.
DR EMBL; AF019008; AAB82505.1; -; Genomic_DNA.
DR EMBL; AF019009; AAB82506.1; -; Genomic_DNA.
DR EMBL; AF019010; AAB82507.1; -; Genomic_DNA.
DR EMBL; AF019011; AAB82508.1; -; Genomic_DNA.
DR EMBL; AF019012; AAB82509.1; -; Genomic_DNA.
DR EMBL; AF019013; AAB82510.1; -; Genomic_DNA.
DR EMBL; AF019014; AAB82511.1; -; Genomic_DNA.
DR EMBL; AF019015; AAB82512.1; -; Genomic_DNA.
DR EMBL; AF019016; AAB82513.1; -; Genomic_DNA.
DR EMBL; AF019017; AAB82514.1; -; Genomic_DNA.
DR EMBL; AF019018; AAB82515.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF57028.1; -; Genomic_DNA.
DR EMBL; AY113583; AAM29588.1; -; mRNA.
DR PIR; S23501; S23501.
DR RefSeq; NP_524591.1; NM_079852.3.
DR AlphaFoldDB; O16829; -.
DR SMR; O16829; -.
DR IntAct; O16829; 2.
DR STRING; 7227.FBpp0084980; -.
DR PaxDb; O16829; -.
DR PRIDE; O16829; -.
DR DNASU; 43599; -.
DR EnsemblMetazoa; FBtr0085616; FBpp0084980; FBgn0000279.
DR GeneID; 43599; -.
DR KEGG; dme:Dmel_CG1373; -.
DR CTD; 43599; -.
DR FlyBase; FBgn0000279; CecC.
DR VEuPathDB; VectorBase:FBgn0000279; -.
DR eggNOG; ENOG502TCNK; Eukaryota.
DR GeneTree; ENSGT00540000073806; -.
DR HOGENOM; CLU_187909_1_0_1; -.
DR InParanoid; O16829; -.
DR OMA; EPIAICN; -.
DR OrthoDB; 1632391at2759; -.
DR PhylomeDB; O16829; -.
DR BioGRID-ORCS; 43599; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CecC; fly.
DR GenomeRNAi; 43599; -.
DR PRO; PR:O16829; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000279; Expressed in saliva-secreting gland and 15 other tissues.
DR ExpressionAtlas; O16829; baseline and differential.
DR Genevisible; O16829; DM.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0019731; P:antibacterial humoral response; IDA:FlyBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0006959; P:humoral immune response; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR000875; Cecropin.
DR InterPro; IPR020400; Cecropin_insect.
DR PANTHER; PTHR38329; PTHR38329; 1.
DR Pfam; PF00272; Cecropin; 1.
DR PROSITE; PS00268; CECROPIN; 1.
PE 2: Evidence at transcript level;
KW Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT CHAIN 24..62
FT /note="Cecropin-C"
FT /id="PRO_0000004848"
FT MOD_RES 62
FT /note="Arginine amide"
FT /evidence="ECO:0000250"
FT VARIANT 5..16
FT /note="KIFVFVALILAI -> MIYVRVGRTQAS (in strain: Z10)"
FT VARIANT 5
FT /note="K -> Q (in strain: B205 and B208)"
FT VARIANT 20
FT /note="Q -> H (in strain: Z10, Z18, Z22 and Z24)"
FT VARIANT 25
FT /note="W -> G (in strain: Z10 and Z22)"
FT VARIANT 26
FT /note="L -> R (in strain: Z24)"
FT VARIANT 26
FT /note="L -> W (in strain: Z10, Z18 and Z22)"
FT VARIANT 27
FT /note="K -> R (in strain: Z10 and Z18)"
FT VARIANT 53
FT /note="Q -> R (in strain: B316)"
FT VARIANT 54
FT /note="A -> T (in strain: B202)"
SQ SEQUENCE 63 AA; 6813 MW; 95686510DA767EDA CRC64;
MNFYKIFVFV ALILAISIGQ SEAGWLKKLG KRIERIGQHT RDATIQGLGI AQQAANVAAT
ARG
