ACCH2_ARATH
ID ACCH2_ARATH Reviewed; 369 AA.
AC Q9C5K7; Q3E7P1; Q9SHK4;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=1-aminocyclopropane-1-carboxylate oxidase homolog 2;
GN OrderedLocusNames=At1g06640; ORFNames=F12K11.27, F12K11.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9C5K7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C5K7-2; Sequence=VSP_041038, VSP_041039;
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24827.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g06630 has been split into 4 genes: At1g06620, At1g06630, At1g06640 and At1g06650.; Evidence={ECO:0000305};
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DR EMBL; AC007592; AAF24827.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28014.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28015.1; -; Genomic_DNA.
DR EMBL; AF360185; AAK25895.1; -; mRNA.
DR EMBL; AY040000; AAK64077.1; -; mRNA.
DR EMBL; AK226396; BAE98542.1; -; mRNA.
DR PIR; D86201; D86201.
DR RefSeq; NP_172149.1; NM_100541.4. [Q9C5K7-1]
DR RefSeq; NP_973774.1; NM_202045.3. [Q9C5K7-2]
DR AlphaFoldDB; Q9C5K7; -.
DR SMR; Q9C5K7; -.
DR STRING; 3702.AT1G06640.1; -.
DR PaxDb; Q9C5K7; -.
DR PRIDE; Q9C5K7; -.
DR ProteomicsDB; 244569; -. [Q9C5K7-1]
DR EnsemblPlants; AT1G06640.1; AT1G06640.1; AT1G06640. [Q9C5K7-1]
DR EnsemblPlants; AT1G06640.2; AT1G06640.2; AT1G06640. [Q9C5K7-2]
DR GeneID; 837173; -.
DR Gramene; AT1G06640.1; AT1G06640.1; AT1G06640. [Q9C5K7-1]
DR Gramene; AT1G06640.2; AT1G06640.2; AT1G06640. [Q9C5K7-2]
DR KEGG; ath:AT1G06640; -.
DR Araport; AT1G06640; -.
DR TAIR; locus:2009210; AT1G06640.
DR eggNOG; KOG0143; Eukaryota.
DR HOGENOM; CLU_010119_0_0_1; -.
DR OMA; YWIDVPH; -.
DR OrthoDB; 755305at2759; -.
DR PhylomeDB; Q9C5K7; -.
DR BioCyc; ARA:AT1G06640-MON; -.
DR PRO; PR:Q9C5K7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C5K7; baseline and differential.
DR Genevisible; Q9C5K7; AT.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.330; -; 1.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Iron; Metal-binding; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..369
FT /note="1-aminocyclopropane-1-carboxylate oxidase homolog 2"
FT /id="PRO_0000274938"
FT DOMAIN 217..318
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 241
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 243
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 297
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT VAR_SEQ 286..322
FT /note="LITNDKFISLKHRVLANRATRARVSVACFFHTHVKPN -> ASLRNQYMFAS
FT SDFTSLFTMLDLFKKSSSWFKVFFFF (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041038"
FT VAR_SEQ 323..369
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041039"
SQ SEQUENCE 369 AA; 41745 MW; 690FA85AB409BF19 CRC64;
MESTKIAPSF DRASELKAFD ETKTGVKGLV DSGISKIPRI FHHSSVELAN PKPLPSDLLH
LKTIPTIDLG GRDFQDAIKH KNAIEGIKEA AAKWGFFQVI NHGVSLELLE KMKDGVRDFH
EQPPEVRKDL YSRDFGRKFI YLSNFDLYTA AAANWRDTFY CYMAPDPPEP QDLPEICRDV
MMEYSKQVMI LGEFLFELLS EALGLNPNHL KDMECLKGLR MLCHYFPPCP EPDLTFGTSK
HSDGSFLTVL LPDNIEGLQV CREGYWFDVP HVPGALIINI GDLLQLITND KFISLKHRVL
ANRATRARVS VACFFHTHVK PNPRVYGPIK ELVSEENPPK YRETTIRDYA TYFNGKGLGG
TSALLDFKV
