CECD_BOMMO
ID CECD_BOMMO Reviewed; 61 AA.
AC O76146;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Cecropin-D;
DE Flags: Precursor;
GN Name=CECD;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC TISSUE=Larval fat body;
RX PubMed=10392453; DOI=10.1016/s0305-0491(99)00015-2;
RA Yang J., Furukawa S., Sagisaka A., Ishibashi J., Taniai K., Shono T.,
RA Yamakawa M.;
RT "cDNA cloning and gene expression of cecropin D, an antibacterial protein
RT in the silkworm, Bombyx mori.";
RL Comp. Biochem. Physiol. 122B:409-414(1999).
CC -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC several Gram-positive and Gram-negative bacteria.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mainly in fat body. Lower in hemocytes. Not
CC expressed in midguts, malpighian tubules and silk glands.
CC {ECO:0000269|PubMed:10392453}.
CC -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:10392453}.
CC -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR EMBL; AB010825; BAA31507.1; -; mRNA.
DR RefSeq; NP_001036833.1; NM_001043368.2.
DR AlphaFoldDB; O76146; -.
DR SMR; O76146; -.
DR STRING; 7091.BGIBMGA000017-TA; -.
DR GeneID; 692369; -.
DR KEGG; bmor:692369; -.
DR CTD; 692369; -.
DR eggNOG; ENOG502TC6E; Eukaryota.
DR HOGENOM; CLU_187909_0_0_1; -.
DR InParanoid; O76146; -.
DR OrthoDB; 1629233at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR000875; Cecropin.
DR Pfam; PF00272; Cecropin; 1.
PE 2: Evidence at transcript level;
KW Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..24
FT /note="Removed by a dipeptidylpeptidase"
FT /id="PRO_0000004828"
FT CHAIN 25..60
FT /note="Cecropin-D"
FT /id="PRO_0000004829"
FT MOD_RES 60
FT /note="Glutamine amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 61 AA; 6436 MW; E63632B6AE8A476E CRC64;
MKFSKIFVFV FAIVFATASV SAAPGNFFKD LEKMGQRVRD AVISAAPAVD TLAKAKALGQ
G