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CECD_BOMMO
ID   CECD_BOMMO              Reviewed;          61 AA.
AC   O76146;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Cecropin-D;
DE   Flags: Precursor;
GN   Name=CECD;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Larval fat body;
RX   PubMed=10392453; DOI=10.1016/s0305-0491(99)00015-2;
RA   Yang J., Furukawa S., Sagisaka A., Ishibashi J., Taniai K., Shono T.,
RA   Yamakawa M.;
RT   "cDNA cloning and gene expression of cecropin D, an antibacterial protein
RT   in the silkworm, Bombyx mori.";
RL   Comp. Biochem. Physiol. 122B:409-414(1999).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mainly in fat body. Lower in hemocytes. Not
CC       expressed in midguts, malpighian tubules and silk glands.
CC       {ECO:0000269|PubMed:10392453}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:10392453}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AB010825; BAA31507.1; -; mRNA.
DR   RefSeq; NP_001036833.1; NM_001043368.2.
DR   AlphaFoldDB; O76146; -.
DR   SMR; O76146; -.
DR   STRING; 7091.BGIBMGA000017-TA; -.
DR   GeneID; 692369; -.
DR   KEGG; bmor:692369; -.
DR   CTD; 692369; -.
DR   eggNOG; ENOG502TC6E; Eukaryota.
DR   HOGENOM; CLU_187909_0_0_1; -.
DR   InParanoid; O76146; -.
DR   OrthoDB; 1629233at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..24
FT                   /note="Removed by a dipeptidylpeptidase"
FT                   /id="PRO_0000004828"
FT   CHAIN           25..60
FT                   /note="Cecropin-D"
FT                   /id="PRO_0000004829"
FT   MOD_RES         60
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   61 AA;  6436 MW;  E63632B6AE8A476E CRC64;
     MKFSKIFVFV FAIVFATASV SAAPGNFFKD LEKMGQRVRD AVISAAPAVD TLAKAKALGQ
     G
 
 
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