ID   CECD_GALME              Reviewed;          39 AA.
AC   P85210;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Cecropin-D-like peptide;
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Larval hemolymph {ECO:0000269|PubMed:11995991};
RX   PubMed=11995991;
RA   Mak P., Chmiel D., Gacek G.J.;
RT   "Antibacterial peptides of the moth Galleria mellonella.";
RL   Acta Biochim. Pol. 48:1191-1195(2001).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   INDUCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Larval hemolymph {ECO:0000269|PubMed:17194500};
RX   PubMed=17194500; DOI=10.1016/j.peptides.2006.11.010;
RA   Cytrynska M., Mak P., Zdybicka-Barabas A., Suder P., Jakubowicz T.;
RT   "Purification and characterization of eight peptides from Galleria
RT   mellonella immune hemolymph.";
RL   Peptides 28:533-546(2007).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. Has antibacterial
CC       activity against the Gram-positive bacteria M.luteus (MIC=34.4 uM),
CC       L.monocytogenes (MIC=34.4 uM), and S.lutea (MIC=34.4 uM), and the Gram-
CC       negative bacterium E.coli D31 (MIC=8.6 uM). Lacks antibacterial
CC       activity against the Gram-positive bacterium B.circulans, and the Gram-
CC       negative bacteria E.coli ATCC 25922 and S.typhimurium. Has antifungal
CC       activity against A.niger, but lacks antifungal activity against
CC       C.albicans, C.wickerhamii, F.oxysporum, P.pastoris, P.tannophilus,
CC       S.cerevisiae, T.harzianum, and Z.marxianus.
CC       {ECO:0000269|PubMed:17194500}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11995991,
CC       ECO:0000269|PubMed:17194500}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|PubMed:11995991,
CC       ECO:0000269|PubMed:17194500}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:11995991,
CC       ECO:0000269|PubMed:17194500}.
CC   -!- MASS SPECTROMETRY: Mass=4255; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11995991, ECO:0000269|PubMed:17194500};
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000255}.
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DR   AlphaFoldDB; P85210; -.
DR   SMR; P85210; -.
DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Immunity;
KW   Innate immunity; Reference proteome; Secreted.
FT   PEPTIDE         1..39
FT                   /note="Cecropin-D-like peptide"
FT                   /id="PRO_0000298770"
SQ   SEQUENCE   39 AA;  4256 MW;  860C0B7E52B9750C CRC64;
     ENFFKEIERA GQRIRDAIIS AAPAVETLAQ AQKIIKGGD