ID   CECP4_ASCSU             Reviewed;          74 AA.
AC   Q5H7N4;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Cecropin-P4;
DE   Flags: Precursor;
GN   Name=ASCEC-4;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   INDUCTION.
RX   PubMed=15850460; DOI=10.1042/bj20050218;
RA   Pillai A., Ueno S., Zhang H., Lee J.M., Kato Y.;
RT   "Cecropin P1 and novel nematode cecropins: a bacteria-inducible
RT   antimicrobial peptide family in the nematode Ascaris suum.";
RL   Biochem. J. 390:207-214(2005).
CC   -!- FUNCTION: Has antibacterial activity against several Gram-positive and
CC       Gram-negative bacteria. Is weakly active against yeasts. Acts by a
CC       nonpore mechanism. {ECO:0000269|PubMed:15850460}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the body wall, intestine, uterus and
CC       ovary. {ECO:0000269|PubMed:15850460}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:15850460}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AB186035; BAD89088.1; -; mRNA.
DR   EMBL; AB186039; BAD89092.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5H7N4; -.
DR   SMR; Q5H7N4; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0002776; P:antimicrobial peptide secretion; IDA:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEP:UniProtKB.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Secreted; Signal.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000250"
FT   CHAIN           14..44
FT                   /note="Cecropin-P4"
FT                   /id="PRO_0000397969"
FT   PROPEP          45..74
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397970"
FT   REGION          51..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   74 AA;  8424 MW;  8101FC21B254CF32 CRC64;
     MFLMYLLVQT TESSWLSKTY KKLENSAKKR ISEGVAIAIL GGLRHRRSVA HQEEASLHVK
     TDELPSPDTV REQL