ID   CECR_SHIFL              Reviewed;         223 AA.
AC   P0ACU1; P41037; P78054;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=HTH-type transcriptional dual regulator CecR {ECO:0000250|UniProtKB:P0ACU0};
GN   Name=cecR {ECO:0000250|UniProtKB:P0ACU0}; Synonyms=ybiH;
GN   OrderedLocusNames=SF0746, S0787;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Regulates transcription of the cecR-ybhGFSR operon and the
CC       rhlE gene, which altogether are involved in the control of sensitivity
CC       to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon
CC       and activates the rhlE operon. Acts by binding to a palindromic
CC       sequence within the intergenic spacer located between these two
CC       divergently transcribed operons. {ECO:0000250|UniProtKB:P0ACU0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0ACU0}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN42381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP16258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN42381.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP16258.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_706674.1; NC_004337.2.
DR   RefSeq; WP_001296991.1; NZ_WPGW01000030.1.
DR   AlphaFoldDB; P0ACU1; -.
DR   SMR; P0ACU1; -.
DR   STRING; 198214.SF0746; -.
DR   PRIDE; P0ACU1; -.
DR   EnsemblBacteria; AAN42381; AAN42381; SF0746.
DR   EnsemblBacteria; AAP16258; AAP16258; S0787.
DR   GeneID; 1026146; -.
DR   GeneID; 58389455; -.
DR   KEGG; sfl:SF0746; -.
DR   KEGG; sfx:S0787; -.
DR   PATRIC; fig|198214.7.peg.867; -.
DR   HOGENOM; CLU_069356_16_0_6; -.
DR   OrthoDB; 2089619at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR015292; Tscrpt_reg_YbiH_C.
DR   Pfam; PF09209; CecR_C; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..223
FT                   /note="HTH-type transcriptional dual regulator CecR"
FT                   /id="PRO_0000070633"
FT   DOMAIN          11..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   223 AA;  25017 MW;  B85EBC247EE8DA86 CRC64;
     MNNPAMTIKG EQAKKQLIAA ALAQFGEYGM NATTREIAAQ AGQNIAAITY YFGSKEDLYL
     ACAQWIADFI GEQFRPHAEE AERLFAQPQP DRAAIRELIL RACRNMIKLL TQDDTVNLSK
     FISREQLSPT AAYHLVHEQV ISPLHSHLTR LIAAWTGCDA NDTRMILHTH ALIGEILAFR
     LGKETILLRT GWTAFDEEKT ELINQTVTCH IDLILQGLSQ RSL