ID   CEC_CALVI               Reviewed;          39 AA.
AC   C0HJX8;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=Cecropin {ECO:0000303|Ref.1};
OS   Calliphora vicina (Blue blowfly) (Calliphora erythrocephala).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=7373 {ECO:0000303|Ref.1};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, INDUCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Hemolymph {ECO:0000303|Ref.1};
RA   Chernysh S., Gordja N.A., Simnonenko N.P.;
RT   "Dia pause and immune response: induction of antimicrobial peptides
RT   synthesis in the blowfly, Calliphora vicina R.-D. (Diptera:
RT   Calliphoridae).";
RL   Entomol. Sci. 3:139-144(2000).
RN   [2] {ECO:0000305}
RP   FUNCTION, INDUCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Hemolymph {ECO:0000303|PubMed:26177023};
RX   PubMed=26177023; DOI=10.1371/journal.pone.0130788;
RA   Chernysh S., Gordya N., Suborova T.;
RT   "Insect antimicrobial peptide complexes prevent resistance development in
RT   bacteria.";
RL   PLoS ONE 10:E0130788-E0130788(2015).
CC   -!- FUNCTION: Antibacterial peptide active against Gram-negative bacterium
CC       E.coli (Ref.1, PubMed:26177023). Has no activity against Gram-positive
CC       bacterium M.luteus (Ref.1). Weakly active against M.luteus
CC       (PubMed:26177023). {ECO:0000269|PubMed:26177023, ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.1}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:26177023,
CC       ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=4156; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- MASS SPECTROMETRY: Mass=4156; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:26177023};
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HJX8; -.
DR   SMR; C0HJX8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   CHAIN           1..39
FT                   /note="Cecropin"
FT                   /id="PRO_0000435612"
SQ   SEQUENCE   39 AA;  4085 MW;  0D979F5918BE094F CRC64;
     GWLKKIGKKI GRVGQHTRDA TIQGLAVAQQ AANVAATAR