ID   CEC_GALME               Reviewed;          65 AA.
AC   A0A6J1WQD0;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   03-AUG-2022, entry version 8.
DE   RecName: Full=Cecropin {ECO:0000303|PubMed:34443685};
DE   Flags: Precursor;
GN   Name=LOC113514368 {ECO:0000312|RefSeq:XP_026754247.1};
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137 {ECO:0000312|Proteomes:UP000504614};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Calla B., Robertson H.M., Grozinger C.M., Robinson G.E., Dolezal A.G.,
RA   Swale T., Shiue L., Berenbaum M.R.;
RT   "Genome sequence of Galleria mellonella, the greater wax moth.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   DEVELOPMENTAL STAGE, AND INDUCTION BY A.NIGER ALPHA-1,3-GLUCAN.
RX   PubMed=34443685; DOI=10.3390/molecules26165097;
RA   Staczek S., Zdybicka-Barabas A., Wojda I., Wiater A., Mak P., Suder P.,
RA   Skrzypiec K., Cytrynska M.;
RT   "Fungal alpha-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in
RT   the Insect Model Host Galleria mellonella.";
RL   Molecules 26:5097-5097(2021).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250|UniProtKB:P01507}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01507}.
CC       Note=Secreted in the hemolymph. {ECO:0000250|UniProtKB:P01507}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fat body of last instar larvae.
CC       {ECO:0000269|PubMed:34443685}.
CC   -!- INDUCTION: Induced by A.niger alpha-1,3-glucan.
CC       {ECO:0000269|PubMed:34443685}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; RBWF02003166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_026754247.1; XM_026898446.2.
DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
PE   2: Evidence at transcript level;
KW   Antimicrobial; Immunity; Innate immunity; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..65
FT                   /note="Cecropin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5026692035"
SQ   SEQUENCE   65 AA;  6999 MW;  58F8B2F2E9E44B33 CRC64;
     MNFVKVLFFI SACILIMLSA VSGAPEPRWK VFKKIERMGQ HIRDGIIKAG PAVAVVGQAS
     TIISG