ID   CEC_GLOMM               Reviewed;          63 AA.
AC   P83403; Q4U3L1;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Cecropin;
DE   Flags: Precursor;
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hu C., Aksoy S.;
RT   "Characterization of antimicrobial peptide cecropin from Glossina morsitans
RT   morsitans.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 24-62, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, INDUCTION, MASS SPECTROMETRY, AND AMIDATION AT ARG-62.
RC   TISSUE=Hemolymph;
RX   PubMed=11886771; DOI=10.1016/s0965-1748(02)00029-2;
RA   Boulanger N., Brun R., Ehret-Sabatier L., Kunz C., Bulet P.;
RT   "Immunopeptides in the defense reactions of Glossina morsitans to bacterial
RT   and Trypanosoma brucei brucei infections.";
RL   Insect Biochem. Mol. Biol. 32:369-375(2002).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-negative bacteria. {ECO:0000269|PubMed:11886771}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:11886771}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11886771}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|PubMed:11886771}.
CC   -!- INDUCTION: By bacterial and parasitic infection.
CC       {ECO:0000269|PubMed:11886771}.
CC   -!- MASS SPECTROMETRY: Mass=4205.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11886771};
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; DQ016433; AAY41177.1; -; mRNA.
DR   AlphaFoldDB; P83403; -.
DR   SMR; P83403; -.
DR   STRING; 37546.P83403; -.
DR   VEuPathDB; VectorBase:GMOY011562; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:11886771"
FT   PEPTIDE         24..62
FT                   /note="Cecropin"
FT                   /id="PRO_0000044680"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000269|PubMed:11886771"
SQ   SEQUENCE   63 AA;  6850 MW;  62053AA59BAEB987 CRC64;
     MNFYKIFVFI ALILALSVSQ SEAGWLKKIG KKIERVGQNT RDATVKGLEV AQQAANVAAT
     VRG