CED11_CAEEL
ID CED11_CAEEL Reviewed; 1418 AA.
AC P34641;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein ced-11;
DE AltName: Full=Cell death protein 11;
GN Name=ced-11; ORFNames=ZK512.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Plays a major role in programmed cell death.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; Z22177; CAA80145.1; -; Genomic_DNA.
DR PIR; S40764; S40764.
DR RefSeq; NP_499021.1; NM_066620.3.
DR AlphaFoldDB; P34641; -.
DR SMR; P34641; -.
DR STRING; 6239.ZK512.3; -.
DR iPTMnet; P34641; -.
DR EPD; P34641; -.
DR PaxDb; P34641; -.
DR PeptideAtlas; P34641; -.
DR PRIDE; P34641; -.
DR EnsemblMetazoa; ZK512.3.1; ZK512.3.1; WBGene00000425.
DR GeneID; 176288; -.
DR KEGG; cel:CELE_ZK512.3; -.
DR UCSC; ZK512.3; c. elegans.
DR CTD; 176288; -.
DR WormBase; ZK512.3; CE00409; WBGene00000425; ced-11.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000168216; -.
DR HOGENOM; CLU_251638_0_0_1; -.
DR InParanoid; P34641; -.
DR OMA; PPFYCKP; -.
DR OrthoDB; 49912at2759; -.
DR PhylomeDB; P34641; -.
DR Reactome; R-CEL-3295583; TRP channels.
DR PRO; PR:P34641; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000425; Expressed in embryo and 3 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IGI:WormBase.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0098655; P:cation transmembrane transport; IBA:GO_Central.
PE 4: Predicted;
KW Apoptosis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1418
FT /note="Protein ced-11"
FT /id="PRO_0000089468"
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 755..775
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 782..802
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 818..838
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 856..876
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 898..918
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 986..1006
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1418 AA; 159238 MW; 4FC83B9E7ADF7788 CRC64;
MDETDPVPDM SLLPDTVPVV VSGDGSAAGI QLCPALILGS PQALPGAIKH IYSRLAAAAS
EVDQGVPDLI ISLISHGNSL STKYMSSVEN GLKSFLIGCG TWLISSGEVN DPMSRVASGA
LKNVLPQLEH QAEVLHILVN SDDMIASDTT NSKSVVDTSL NTLLLICRKE PNDSYETVAS
SIAKLRAATA VKLAHPPPAL LIGVPSEPMS PSTYGNSAAI LLSPSNDKRP FPVAIFAGAS
KESLIELLFF VEHGIPVIIL QDSCELCAIL HSSHLLLETS NFDNDKFISW LRSQLYPLGL
ADCYTLITKL LVSSNSGDVQ LIEFIDSSQL SELSSVVVDR CLECYATTGE ERQVLLLAAK
LNSPSVLSSM DVAAQLDEEL LTMILCECIT KDDQLHFLSS VLQLSPPIRV TSNMLIRMMH
HADEHFFTTI VLCQCMGYSY IPSEIDPRFA NDIQKLVKKL SFGVDNLFDP NVFCNDSSHR
DKHESIRILA IWSLLLHRPG IVKCLAAFAD EPVAFSMVLS RIARSLGHES HDWHFYEKSL
NTLSDSLSGS ATTLFDTVFS TSPAKAYQLL CQPMEYFYGF NMTQLAFHCN AREIIAHECC
QRWVHRKLYG NLQAKNFPIF LPKWAKICIS AVLIIPVKFW MLVRPRERTK QDTVSPTVAL
LDVGKFPQKQ RAISTYSVIS SRSEALTALT APLSTAFGFN SALNGAESAT PQSMVFPLNI
EEIDKDPRPF GKKNRIRRAH APTLSTFYST PIVKYWLSLL FRIVFICCLA YSVVLPGCGS
NLWDTGMWVW SFFWWIENCF VLTARARKIP LSLMPWRVFD VFAFFVFLIL LLVMKVFPVT
PVLEVLGIDS IYSAKVVSAF FVLYVSYSTL FTYIPLSDIF GPMIVRVKLM LLRDFTNFLF
MIALVMLSSA VAIQAVVFPD RPVTMEVFRK TLSWIWLSLF TTDLSNLSES ETCRKSFLGA
PKRYCSSVGQ YANPSCPSQS LPAYLIVIEY FVILKLLLWP ILFAFFSKTA KNVDDEADKI
WRFQLYSLAE DFRLRPPLPP PLTIFCLICS ACCRFSNSFS GFFSDFDHPD FEARDKCRTT
WKFGSIYRNP SVPFKRNEFV NSFWRKLSME QWKNTQQKAK ISANKSELQE LHNIHNHIRM
MTLRDSYENS GTRKASELQF FEKYPESNIL KISVNMVSKP WTVLVPRYNP PFYCKPAEDF
PSDVQKYVDI ATEQNVGELK RIWRSRQAND VTSSNDKCWK LSAAGFPLNP NGRTGMAGRG
NHPRFGANRR CYYVVLSGGV EAKCQVLVDS QKNIPNEWHL ENSSKDEHLT SILKMIGISD
SDAHMFSMRR LDSSIITADK RIPSNDTSPA HLASEVAENE NDTDNAWTEH DVWAISLRER
RIITTIIGYS WLPTSAIRGT VLPWQADLVF RAKTIYGL
