ID   CEDA_ECOLI              Reviewed;          80 AA.
AC   P0AE60; P76211; Q2MB43;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cell division activator CedA;
GN   Name=cedA; Synonyms=ydjP; OrderedLocusNames=b1731, JW1720;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=9427399; DOI=10.1046/j.1365-2958.1997.5941967.x;
RA   Katayama T., Takata M., Sekimizu K.;
RT   "CedA is a novel Escherichia coli protein that activates the cell division
RT   inhibited by chromosomal DNA over-replication.";
RL   Mol. Microbiol. 26:687-697(1997).
RN   [4]
RP   STRUCTURE BY NMR, AND DNA-BINDING.
RX   PubMed=15865419; DOI=10.1021/bi0500269;
RA   Chen H.A., Simpson P., Huyton T., Roper D., Matthews S.;
RT   "Solution structure and interactions of the Escherichia coli cell division
RT   activator protein CedA.";
RL   Biochemistry 44:6738-6744(2005).
RN   [5]
RP   STRUCTURE BY NMR OF 19-80.
RA   Abe Y., Watanabe N., Matsuda Y., Yoshida Y., Katayama T., Ueda T.;
RT   "Structural analysis and molecular interaction of cell division
RT   reactivation factor, cedA from Escherichia coli.";
RL   Submitted (SEP-2005) to the PDB data bank.
CC   -!- FUNCTION: Activates the cell division inhibited by chromosomal DNA
CC       over-replication.
CC   -!- MISCELLANEOUS: In vitro, binds double-stranded DNA, but not single-
CC       stranded DNA.
CC   -!- SIMILARITY: Belongs to the CedA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE76513.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U00096; AAC74801.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76513.1; ALT_INIT; Genomic_DNA.
DR   PIR; C64932; C64932.
DR   RefSeq; NP_416245.2; NC_000913.3.
DR   PDB; 2BN8; NMR; -; A=1-80.
DR   PDB; 2D35; NMR; -; A=19-80.
DR   PDBsum; 2BN8; -.
DR   PDBsum; 2D35; -.
DR   AlphaFoldDB; P0AE60; -.
DR   SMR; P0AE60; -.
DR   BioGRID; 4260304; 400.
DR   DIP; DIP-47928N; -.
DR   IntAct; P0AE60; 14.
DR   STRING; 511145.b1731; -.
DR   jPOST; P0AE60; -.
DR   PaxDb; P0AE60; -.
DR   PRIDE; P0AE60; -.
DR   EnsemblBacteria; AAC74801; AAC74801; b1731.
DR   EnsemblBacteria; BAE76513; BAE76513; BAE76513.
DR   GeneID; 946235; -.
DR   KEGG; ecj:JW1720; -.
DR   KEGG; eco:b1731; -.
DR   PATRIC; fig|511145.12.peg.1802; -.
DR   EchoBASE; EB3748; -.
DR   eggNOG; ENOG5032S26; Bacteria.
DR   HOGENOM; CLU_167445_0_0_6; -.
DR   OMA; HAIKMDA; -.
DR   PhylomeDB; P0AE60; -.
DR   BioCyc; EcoCyc:G6936-MON; -.
DR   EvolutionaryTrace; P0AE60; -.
DR   PRO; PR:P0AE60; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IDA:EcoCyc.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.730.20; -; 1.
DR   HAMAP; MF_01580; CedA; 1.
DR   InterPro; IPR038463; CedA-like_sf.
DR   InterPro; IPR019666; Cell_div_activator_CedA.
DR   Pfam; PF10729; CedA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..80
FT                   /note="Cell division activator CedA"
FT                   /id="PRO_0000089471"
FT   TURN            30..32
FT                   /evidence="ECO:0007829|PDB:2BN8"
FT   STRAND          36..39
FT                   /evidence="ECO:0007829|PDB:2BN8"
FT   STRAND          42..46
FT                   /evidence="ECO:0007829|PDB:2BN8"
FT   STRAND          49..51
FT                   /evidence="ECO:0007829|PDB:2BN8"
FT   STRAND          53..55
FT                   /evidence="ECO:0007829|PDB:2D35"
FT   STRAND          59..61
FT                   /evidence="ECO:0007829|PDB:2BN8"
FT   HELIX           62..74
FT                   /evidence="ECO:0007829|PDB:2BN8"
SQ   SEQUENCE   80 AA;  9377 MW;  69CFC7E3EF709D72 CRC64;
     MKKPLRQQNR QIISYVPRTE PAPPEHAIKM DSFRDVWMLR GKYVAFVLMG ESFLRSPAFT
     VPESAQRWAN QIRQEGEVTE