ID   CEF1_ASHGO              Reviewed;         477 AA.
AC   Q756C3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Pre-mRNA-splicing factor CEF1;
GN   Name=CEF1; OrderedLocusNames=AER344W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in mRNA splicing and cell cycle control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC   -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS53024.1; -; Genomic_DNA.
DR   RefSeq; NP_985200.1; NM_210554.1.
DR   AlphaFoldDB; Q756C3; -.
DR   SMR; Q756C3; -.
DR   STRING; 33169.AAS53024; -.
DR   EnsemblFungi; AAS53024; AAS53024; AGOS_AER344W.
DR   GeneID; 4621414; -.
DR   KEGG; ago:AGOS_AER344W; -.
DR   eggNOG; KOG0050; Eukaryota.
DR   HOGENOM; CLU_572333_0_0_1; -.
DR   InParanoid; Q756C3; -.
DR   OMA; ECISHGE; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51294; HTH_MYB; 1.
DR   PROSITE; PS50090; MYB_LIKE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..477
FT                   /note="Pre-mRNA-splicing factor CEF1"
FT                   /id="PRO_0000197094"
FT   DOMAIN          1..58
FT                   /note="HTH myb-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          59..104
FT                   /note="Myb-like"
FT   DNA_BIND        33..56
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          233..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  51722 MW;  94C5592C355FA43A CRC64;
     MPAVPIYVKG GVWSTVEDEI LRAAVQRYGT HAWNKVASLL PRKSGKQCRA RWEESVRPTR
     QGAWTAAEDA TLAALARGGP QWRSVGAALG RPAAACAARW AELTGDQAVA GPAAGERIPG
     AEGLPAVPEE DEREMVAEAR ARLASTQGKK AARRARERQV EESRRVARLQ KRRALLQAGV
     NSALPLPRAV RGQLDPNADV LYELAPAEGV FETANEAARD RAAREAYERQ IEARGKRTAR
     KQSRAPARAP ATEQPALQVR RAIPRPPLEL PVPEALLKNS AAPTAAVRRA LARLWQGLPA
     AKNDFDVAPE SEDEQPSGSA DAAVQSTDME VLLPWEPPLR QDLPPPPPPP PGLLAEHYRA
     LAAAAAGGPA CYDTPDVLRQ REAIERALAA EPSPAMLHPQ CELPRLPSLD ALRAAAQPRP
     QRRLAAHAAT DAGSRLLAYE LLPDLATKQR EYYVRYTAYE LERTAVATRV RRLTAGR