CEF1_ASPFU
ID CEF1_ASPFU Reviewed; 792 AA.
AC Q4WHG0;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Pre-mRNA-splicing factor cef1;
GN Name=cef1; ORFNames=AFUA_2G05540;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR EMBL; AAHF01000008; EAL87645.1; -; Genomic_DNA.
DR RefSeq; XP_749683.1; XM_744590.1.
DR AlphaFoldDB; Q4WHG0; -.
DR SMR; Q4WHG0; -.
DR STRING; 746128.CADAFUBP00002203; -.
DR EnsemblFungi; EAL87645; EAL87645; AFUA_2G05540.
DR GeneID; 3506710; -.
DR KEGG; afm:AFUA_2G05540; -.
DR VEuPathDB; FungiDB:Afu2g05540; -.
DR eggNOG; KOG0050; Eukaryota.
DR HOGENOM; CLU_009082_0_0_1; -.
DR InParanoid; Q4WHG0; -.
DR OMA; PFRTQRE; -.
DR OrthoDB; 975557at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR021786; Cdc5p/Cef1_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF11831; Myb_Cef; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; DNA-binding; mRNA processing; mRNA splicing;
KW Nucleus; Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..792
FT /note="Pre-mRNA-splicing factor cef1"
FT /id="PRO_0000197095"
FT DOMAIN 1..56
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 57..106
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 29..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 80..102
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 111..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 705..780
FT /evidence="ECO:0000255"
FT COMPBIAS 128..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 88588 MW; 3E77F4FD7CA39091 CRC64;
MPVVKGGVWT NIEDEVLRAA VSKYGLNQWA RVSSLLARKT PKQCKARWVE WLDPGIRKVE
WSREEDEKLL HLAKLMPTQW RTIAPIVGRT ATQCLERYQK LLDEAEAREN DELGLGGPSG
GEAAAPSADD VRRLRPGELD PDPESKPARP DTIDLDEDEK EMLSEARARL ANTQGKKAKR
KARERQLEES RRLAVLQKRR ELKNAGINIK VVTRKKGEMD YNADIPFEKP AAPGFYDTTE
EEARNERQRE MFDPRKQQLA NKRKGDQEED ADRKKRKNDK NGSSAFAAAA RAGQMQKIRE
AEQSSKRRAL VLPAPQVSES EMEDIIKMGM AGDRASKMSG DDETTRGLIG NYTSIVGGTP
IRTPRAPPEE DHIANEIRNI RALTETQSSL LGGENTPLHE GGSSTGFDGI APRRQQIVTP
NPMATPFRQA NGLGATPLHG GIGPGATPLR TPRDQFALNQ MEGGQLIGTT PRDIRLHQKA
VSQAIRSKLA SLPKPKETEW ELEELPSESA EPTVAAEISE EDAAERDRRE REARERAAQA
ELKRQTQVYQ RGLPRPSVLD IDALMARASQ VTDPINGMIA KEAALLIAND AQKFRLPNGK
VEGKARKLER LNDELIEAAR AAIVAEVASS NQQQEWLQGF DDRWSSTHSN ALPGLANYGD
DDEDENMYRQ EQRMIDAFEN VQASLLATAE RGNKLEKKLA LHYGGYQNRA KTLRTKIVEA
SSALENSKYE LNAFQTLQIS EESAISRRLE KLRDDVAFVL KREREAQETY RIRKEELDEL
VAGTEAVVNG WH
