ID   CEF1_CANAL              Reviewed;         610 AA.
AC   Q5APG6; A0A1D8PEK2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Pre-mRNA-splicing factor CEF1;
GN   Name=CEF1; OrderedLocusNames=CAALFM_C109370WA;
GN   ORFNames=CaO19.12262, CaO19.4799;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC   -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26571.1; -; Genomic_DNA.
DR   RefSeq; XP_723485.2; XM_718392.2.
DR   AlphaFoldDB; Q5APG6; -.
DR   SMR; Q5APG6; -.
DR   STRING; 237561.Q5APG6; -.
DR   PRIDE; Q5APG6; -.
DR   GeneID; 3634808; -.
DR   KEGG; cal:CAALFM_C109370WA; -.
DR   CGD; CAL0000201853; CEF1.
DR   VEuPathDB; FungiDB:C1_09370W_A; -.
DR   eggNOG; KOG0050; Eukaryota.
DR   HOGENOM; CLU_009082_2_0_1; -.
DR   InParanoid; Q5APG6; -.
DR   OMA; PPLYVKG; -.
DR   OrthoDB; 975557at2759; -.
DR   PRO; PR:Q5APG6; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0140602; C:nucleolar ring; IEA:EnsemblFungi.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 2.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51294; HTH_MYB; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; DNA-binding; mRNA processing; mRNA splicing;
KW   Nucleus; Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..610
FT                   /note="Pre-mRNA-splicing factor CEF1"
FT                   /id="PRO_0000197096"
FT   DOMAIN          1..55
FT                   /note="HTH myb-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          56..109
FT                   /note="HTH myb-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        32..55
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        83..105
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          142..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          162..206
FT                   /evidence="ECO:0000255"
FT   COILED          337..368
FT                   /evidence="ECO:0000255"
FT   COILED          585..610
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   610 AA;  70172 MW;  DBFCB6B67FB7DFA0 CRC64;
     MAPPLYVKGG VWTNVEDEIL KAAIQKYGIY QWERISSLLP KKSAKQVKAR WVEYLSPLLN
     KTDWTKEEDE KLLNLHKIFP NQWRSISNIL NRTAVQCVER YQKLIDEAAG IKPGDDEENL
     GLSGPGIETL PAVGASSGLA VGEMNLNPES KPARPDDEDL PDDEREMLAE AKARLGNIQG
     KKAKRKARER MLEESKRIAL LQKRRELKSA GINVKLTTRN KKKRKEFDYN ADIPHEIIPQ
     AGPYDTAEEL KQNDFEKQQF GQQVSTKGIS MKDIDDRIAK EESRRKKEIE KKKLERKREF
     NAAASLISEH EDSKRRKLNL PEPGTHNFEK TKSDVLTLTN QANNKLSEKE IARNQNKKRA
     AVAQLIKATF ERLPPPKHET GEILPFVSTN ILEFRNDVNA NDISDIAGAK LPDETATNVS
     TLISRVVQRE LPIPHPNNLR DLSTVKFDTL VDKLIAEECH RLIRSDYKQY HDTTINGVST
     DKYDRDLLEK INQDIDKEFA QMDVSTVHSF EDYVLPKNFK VAESIIENLH TFHNENEKLT
     NKILESTNYE DQRDQKLQQL THLWRELSDV NLSYSIEKKL FELESSAIDK ELLRLRSEID
     KLNKKIETLR