CEF1_CRYNJ
ID CEF1_CRYNJ Reviewed; 838 AA.
AC P0CO94; Q55JY9; Q5K9L1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Pre-mRNA-splicing factor CEF1;
GN Name=CEF1; OrderedLocusNames=CNK01590;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR EMBL; AE017351; AAW46316.1; -; Genomic_DNA.
DR RefSeq; XP_567833.1; XM_567833.1.
DR AlphaFoldDB; P0CO94; -.
DR SMR; P0CO94; -.
DR STRING; 5207.AAW46316; -.
DR PaxDb; P0CO94; -.
DR PRIDE; P0CO94; -.
DR EnsemblFungi; AAW46316; AAW46316; CNK01590.
DR GeneID; 3254565; -.
DR KEGG; cne:CNK01590; -.
DR VEuPathDB; FungiDB:CNK01590; -.
DR eggNOG; KOG0050; Eukaryota.
DR HOGENOM; CLU_009082_0_0_1; -.
DR InParanoid; P0CO94; -.
DR OMA; PFRTQRE; -.
DR OrthoDB; 975557at2759; -.
DR Proteomes; UP000002149; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR021786; Cdc5p/Cef1_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF11831; Myb_Cef; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; DNA-binding; mRNA processing; mRNA splicing;
KW Nucleus; Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..838
FT /note="Pre-mRNA-splicing factor CEF1"
FT /id="PRO_0000197098"
FT DOMAIN 2..57
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 58..107
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 30..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 81..103
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 114..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 250..311
FT /evidence="ECO:0000255"
FT COILED 727..813
FT /evidence="ECO:0000255"
FT COMPBIAS 255..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..516
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 93254 MW; 682DC9EB0E1E61E9 CRC64;
MRVIVKGGVW RNTEDEILKA AISKYGKNQW ARISSLLVRK TPKQCKARWY EWLDPSIKKV
EWSKTEDEKL LHLAKLMPTQ WRTIAPIVGR TATQCLERYQ KLLDDAEARD NEELGLGAGE
DESSKPATDA RGLRPGEIDT DPETRPARPD PIDMDDDEKE MLSEARARLA NTQGKKAKRK
ARERQLEEAR RLAFLQKKRE LKAAGINLRA KPKKKGMDYN ADIPFEKQPA PGFYDVTEEQ
AKVHAAPVGS TLRALEGKRK QELDEIEERK KRQKKGDGKS NQTQQFVAAR EAQIKKLKEQ
EQIIRRRKLN LPIPQVGERE LEDIVKIGQA GELARELVGD GNKATEGLLG EYEALGQAKM
ARTPRTAPQQ DNVMAEARNL RNMMAAQTPL LGEENTPLHG PSVGTGFEGA TPRHDVAATP
NPLATSARGG VLTSTRTVPG VGTTPLRTPF RDDLNINDDA SVYGETPMND RRRLAESRRA
LKAGFAALPK PENNFELAET EEDEEEAEEA EPLTEEDAAE RDARLKAARE EEERRELERR
STVIKKGLPR PVNVNTYKLL DDLNSAIVEQ TDEEMAAAFK LVNLEVAMLM KHDSIAHPLP
GTSTPGGLAS EYDMPEDDFV AEAKNAIHTE LANALGLPGA SDEHLRLAIG AAAEENEAAF
AEAWAEEREG LVYSPSTRTW VDKTSLSPEE LSACYAAMIN ASRDRVIAEA TKAAKAEKKL
GKQLGGYQTL NEKAKKAIVD VMEEIHQTKR DMETFLMLKG IEEAAAPARL EKIREEVAVL
KKRERDLQAR YAELNDRRRE NLAAIEQLEE DKIVLAAQVA LEAQEGEVAD GDVDMNGA
