ID   CEF1_EMENI              Reviewed;         791 AA.
AC   C8VBH3; Q5AW35;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Pre-mRNA-splicing factor cef1;
GN   Name=cef1; ORFNames=AN10944;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC   -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA62075.1; Type=Erroneous gene model prediction; Note=The predicted gene AN7495 has been split into 2 genes: AN10944 and AN10956.; Evidence={ECO:0000305};
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DR   EMBL; AACD01000129; EAA62075.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001304; CBF79492.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8VBH3; -.
DR   SMR; C8VBH3; -.
DR   STRING; 162425.CADANIAP00000590; -.
DR   PRIDE; C8VBH3; -.
DR   EnsemblFungi; CBF79492; CBF79492; ANIA_10944.
DR   EnsemblFungi; EAA62075; EAA62075; AN7495.2.
DR   VEuPathDB; FungiDB:AN10944; -.
DR   eggNOG; KOG0050; Eukaryota.
DR   HOGENOM; CLU_005700_0_0_1; -.
DR   InParanoid; C8VBH3; -.
DR   OMA; PFRTQRE; -.
DR   OrthoDB; 975557at2759; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR021786; Cdc5p/Cef1_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF11831; Myb_Cef; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51294; HTH_MYB; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; DNA-binding; mRNA processing; mRNA splicing;
KW   Nucleus; Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..791
FT                   /note="Pre-mRNA-splicing factor cef1"
FT                   /id="PRO_0000197100"
FT   DOMAIN          1..56
FT                   /note="HTH myb-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          57..106
FT                   /note="HTH myb-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        29..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        80..102
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          110..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          523..551
FT                   /evidence="ECO:0000255"
FT   COILED          705..779
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        127..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   791 AA;  88457 MW;  2B00D5C52CE9791F CRC64;
     MPVVKGGVWT NIEDEVLRAA VSKYGLNQWA RVSSLLARKT PKQCKARWVE WLDPGIRKVE
     WSREEDEKLL HLAKLMPTQW RTIAPIVGRT ATQCLERYQK LLDEAEAREN DELGLGGPGT
     EASAPSADDV RRLRPGELDP DPESKPARPD TIDLDEDEKE MLSEARARLA NTQGKKAKRK
     ARERQLEESR RLAVLQKRRE LKNAGINIKI VTRKPGEMDY NADIPFEKPA APGFYDTTEE
     EARNERQREM FDPRKQQLAN KRKGDQDEEA ERKKRKNDKN SNSAAFAAAA RAGQMQKIRE
     AEQSSKRRAL VLPTPQVSES EMEDIIKMGM AGDKASKMVG DEEGTKGLLG NYSAMVGGTP
     IRTPRAPPEE DHIANEIRNI RALTETQSSL LGGENTPLHD GGSSTGFDGI APRRQQIVTP
     NPMATPFRQG NAVSATPVPG GAGPGATPLR TPRDHFSLNK EISGGLPIGS TPREIKMREN
     LARQSIRGRL AALPKPKETE WELEQLPSES AEPAGATEYP EEDSAVRDAR EKEIRKRAAE
     AEHKRQTQVY QRSLPRPVVL DIDALMERAS RVMDPITGLI AKEAALLVAN DACKFATPGA
     KIEGKPRKLE RLDDKYLEEA RAAIASEASS GKLEEWSNEF DAKWSSSRQD TLPGLSNYLD
     DDEEDAYQQE QRIIGVFDNV QASLLATAED GNKLEKKLAL HYGGYQNRAK MLRAKITEAH
     TALEKSKHEL DAFRTLQISE EAAISRRLEK LREEVAFVMR REREAQEQYR CRKDELDDLV
     ASTGGMVNGW H