CEF1_MAGO7
ID CEF1_MAGO7 Reviewed; 773 AA.
AC Q52G60; A4RKP8; G4MZK9;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Pre-mRNA-splicing factor CEF1;
GN Name=CEF1; ORFNames=MGG_01426;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR EMBL; CM001232; EHA54568.1; -; Genomic_DNA.
DR RefSeq; XP_003714375.1; XM_003714327.1.
DR PDB; 6JUI; X-ray; 2.40 A; A=1-106.
DR PDBsum; 6JUI; -.
DR AlphaFoldDB; Q52G60; -.
DR SMR; Q52G60; -.
DR STRING; 318829.MGG_01426T0; -.
DR EnsemblFungi; MGG_01426T0; MGG_01426T0; MGG_01426.
DR GeneID; 2679320; -.
DR KEGG; mgr:MGG_01426; -.
DR VEuPathDB; FungiDB:MGG_01426; -.
DR eggNOG; KOG0050; Eukaryota.
DR HOGENOM; CLU_009082_0_0_1; -.
DR InParanoid; Q52G60; -.
DR OMA; PFRTQRE; -.
DR OrthoDB; 975557at2759; -.
DR PHI-base; PHI:2991; -.
DR Proteomes; UP000009058; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR021786; Cdc5p/Cef1_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF11831; Myb_Cef; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Cytoplasm; DNA-binding; mRNA processing;
KW mRNA splicing; Nucleus; Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..773
FT /note="Pre-mRNA-splicing factor CEF1"
FT /id="PRO_0000197102"
FT DOMAIN 1..56
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 57..106
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 29..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 80..102
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 114..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 156..203
FT /evidence="ECO:0000255"
FT COILED 648..754
FT /evidence="ECO:0000255"
FT COMPBIAS 132..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 11..24
FT /evidence="ECO:0007829|PDB:6JUI"
FT HELIX 29..34
FT /evidence="ECO:0007829|PDB:6JUI"
FT STRAND 36..38
FT /evidence="ECO:0007829|PDB:6JUI"
FT HELIX 41..50
FT /evidence="ECO:0007829|PDB:6JUI"
FT HELIX 63..75
FT /evidence="ECO:0007829|PDB:6JUI"
FT TURN 81..86
FT /evidence="ECO:0007829|PDB:6JUI"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:6JUI"
FT HELIX 91..106
FT /evidence="ECO:0007829|PDB:6JUI"
SQ SEQUENCE 773 AA; 86096 MW; 438298C909F8B579 CRC64;
MPVVKGGVWT NIEDEILKAS VSKYGLNQWA RVSSLLARKT PKQCKARWNE WLDPSIRKIE
WSKDEDEKLL HLAKLMPTQW RTIAPIVGRT ANQCLERYQK LLDEAEQKEA AAALGLTGTG
EASAPTADSV RRLRPGEIDP DPETKPAKAD TVDLDEDEKE MLSEARARLA NTQGKKAKRK
ARERQQEESR RLAALQKRRE LKTAGINVKV TTRKPGQMDY NADIPFEQKP APGFYDTSEE
LARNERERAA FDPKKVQLAT KRKGDQDEDA DRKRRKNDKE GSQSASLQEA LKAGRMQKMR
EAEQSSKRRA LVLPEPQVGE GELEDIVKMG MIGERAGQMA RESENDATRG LVGSYSSLNT
GAPIRTPRAP EQEDHIANEI RNIRALQETQ SSLLGGENTP LHEGVASTGF DGVAPRKQVM
STPNPLATPM RSGANGMGMT PGGPGATPRA PGQTPLRTPR DGFSLNSVGD EVASRQQLLK
GLAALPKPKE TEWDLELPED QMEVDAAEAL EEDASERDRR EREIREAQEA LERRRRTQVM
QRDLPRPAVV DIDLFLKHAD SIPDPSQSMV AREAAMLMAN DAIKFPAAGV KPARSSKVQV
EQVDDAALAE ARLQVLVEAG SAPKPEDVQK AWDREKSNSL LLGLACYDDD EEEEQVAIMR
AALEEVQQSI VSSAEKGNKL EKKLNLHHGG YKQRAEMLRK KIGEASEALS KANDALSAFK
TLAVSEEITI TRRLEALREE VAYVSRRERE AQELYRRIRE ESDHMPVVTN GYH
