CEF1_YARLI
ID CEF1_YARLI Reviewed; 719 AA.
AC Q6C8F5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Pre-mRNA-splicing factor CEF1;
GN Name=CEF1; OrderedLocusNames=YALI0D20086g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR EMBL; CR382130; CAG81249.1; -; Genomic_DNA.
DR RefSeq; XP_503057.1; XM_503057.1.
DR AlphaFoldDB; Q6C8F5; -.
DR SMR; Q6C8F5; -.
DR STRING; 4952.CAG81249; -.
DR EnsemblFungi; CAG81249; CAG81249; YALI0_D20086g.
DR GeneID; 2911197; -.
DR KEGG; yli:YALI0D20086g; -.
DR VEuPathDB; FungiDB:YALI0_D20086g; -.
DR HOGENOM; CLU_009082_0_0_1; -.
DR InParanoid; Q6C8F5; -.
DR OMA; PPLYVKG; -.
DR Proteomes; UP000001300; Chromosome D.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0140602; C:nucleolar ring; IEA:EnsemblFungi.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR021786; Cdc5p/Cef1_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF11831; Myb_Cef; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; DNA-binding; mRNA processing; mRNA splicing;
KW Nucleus; Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..719
FT /note="Pre-mRNA-splicing factor CEF1"
FT /id="PRO_0000197106"
FT DOMAIN 1..56
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 57..106
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 29..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 80..102
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 113..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 252..286
FT /evidence="ECO:0000255"
FT COILED 687..716
FT /evidence="ECO:0000255"
FT COMPBIAS 130..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 81059 MW; CC39120A0191161F CRC64;
MAYVKGGVWT NVEDEILRAA ISKYGLNQWA RVSSLLARKT AKQCKARWTE WLDPTIKKIE
WSREEDEKLL HLAKIFPAQW RTIAPFVGRT AHQCIQRYER LLAEVAGEVE GEDASAVASA
PATEGDQFPE TKPARPDAVD MDEDEKEMLS EARARLANTQ GKKAKRKDRE RMLEDSRRLS
QLQKRRELKN AGIDTRLSKR KKNEMDYNAD IPFEHKPARG FYSTAEEEHE NDSERLQHKQ
MHRTAADAPG PSQKRDKATL SKEDEEKKKE QQKTASAQRT LQLAQLDLQD QISKRRKLNL
PEPQIQDQEM EEIVKLGAQG EALHKRYADG VASSLSGDYD DKIVDDSIRT PQIQQSKVKT
TIEEIKAMEN RSVLGKRTEE EVDDEAEADK DGFAIPKLPS NKAVTSVSAG SDIGGATPAG
MTPIKRDALG LVGSVEATPV SILRQKLASL PKPKNDFEIT AEDEEEDEEA DKEKKPTDNL
PVDKGEQARL KRIAEEQERQ EALKTRSQTL QRGLPRATVP EVTYNDAIGQ EVVALLREEE
LRFPNKGDSV ALMQSEFSLD DLVDAETLIE MELMEGDEQE VQEEGIKTAA LPGTVARSDE
SEEEFKTRVE IISDQLVETL TSLAETCQTE ETALVDKFKA YAKRQATLSK KLTSRWSQLE
SVEVEIAVFS ELARMEEIAI EQRSAALQEE VDWLVKKERA AQDKYRELKV KEQAAKGGH
