CEFIP_HUMAN
ID CEFIP_HUMAN Reviewed; 1435 AA.
AC Q711Q0; A0AVL8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cardiac-enriched FHL2-interacting protein {ECO:0000303|PubMed:28717008};
GN Name=CEFIP {ECO:0000303|PubMed:28717008}; Synonyms=C10orf71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LYS-208;
RP LEU-320; ALA-461; SER-698 AND ASN-883.
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS LEU-320
RP AND ALA-461.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 870-1435 (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RA Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.;
RT "Full length sequencing of some human and murine muscular transcripts
RT (Telethon Italy project B41).";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120; SER-323; SER-470 AND
RP SER-816, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP TISSUE SPECIFICITY, AND INTERACTION WITH FHL2.
RX PubMed=28717008; DOI=10.1074/jbc.m117.786764;
RA Dierck F., Kuhn C., Rohr C., Hille S., Braune J., Sossalla S., Molt S.,
RA van der Ven P.F.M., Fuerst D.O., Frey N.;
RT "The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy
RT by modulating calcineurin signaling.";
RL J. Biol. Chem. 292:15180-15191(2017).
CC -!- FUNCTION: Plays an important role in cardiomyocyte hypertrophy via
CC activation of the calcineurin/NFAT signaling pathway.
CC {ECO:0000250|UniProtKB:M0RD54}.
CC -!- SUBUNIT: Interacts with FHL2. {ECO:0000269|PubMed:28717008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC {ECO:0000250|UniProtKB:M0RD54}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q711Q0-1; Sequence=Displayed;
CC Name=3;
CC IsoId=Q711Q0-3; Sequence=VSP_024267, VSP_024268;
CC -!- TISSUE SPECIFICITY: Expressed in the heart and skeletal muscle.
CC {ECO:0000269|PubMed:28717008}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC85340.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK127811; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL833265; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC027674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126413; AAI26414.1; -; mRNA.
DR EMBL; AJ311357; CAC85340.1; ALT_FRAME; mRNA.
DR CCDS; CCDS44387.1; -. [Q711Q0-1]
DR RefSeq; NP_001128668.1; NM_001135196.1. [Q711Q0-1]
DR RefSeq; XP_005269533.1; XM_005269476.4. [Q711Q0-1]
DR RefSeq; XP_005269534.1; XM_005269477.3. [Q711Q0-1]
DR RefSeq; XP_005269535.1; XM_005269478.4. [Q711Q0-1]
DR AlphaFoldDB; Q711Q0; -.
DR BioGRID; 125609; 8.
DR IntAct; Q711Q0; 6.
DR STRING; 9606.ENSP00000363259; -.
DR iPTMnet; Q711Q0; -.
DR PhosphoSitePlus; Q711Q0; -.
DR BioMuta; C10orf71; -.
DR DMDM; 143955302; -.
DR MassIVE; Q711Q0; -.
DR PaxDb; Q711Q0; -.
DR PeptideAtlas; Q711Q0; -.
DR PRIDE; Q711Q0; -.
DR ProteomicsDB; 68588; -. [Q711Q0-1]
DR ProteomicsDB; 68589; -. [Q711Q0-3]
DR Antibodypedia; 50031; 26 antibodies from 10 providers.
DR DNASU; 118461; -.
DR Ensembl; ENST00000374144.8; ENSP00000363259.3; ENSG00000177354.12. [Q711Q0-1]
DR GeneID; 118461; -.
DR KEGG; hsa:118461; -.
DR MANE-Select; ENST00000374144.8; ENSP00000363259.3; NM_001135196.2; NP_001128668.1.
DR UCSC; uc021pqa.3; human. [Q711Q0-1]
DR CTD; 118461; -.
DR DisGeNET; 118461; -.
DR GeneCards; C10orf71; -.
DR HGNC; HGNC:26973; C10orf71.
DR HPA; ENSG00000177354; Group enriched (skeletal muscle, tongue).
DR neXtProt; NX_Q711Q0; -.
DR OpenTargets; ENSG00000177354; -.
DR PharmGKB; PA134920715; -.
DR VEuPathDB; HostDB:ENSG00000177354; -.
DR eggNOG; ENOG502QVE3; Eukaryota.
DR GeneTree; ENSGT00730000111333; -.
DR HOGENOM; CLU_255771_0_0_1; -.
DR InParanoid; Q711Q0; -.
DR OMA; HYSPPFN; -.
DR OrthoDB; 416362at2759; -.
DR PhylomeDB; Q711Q0; -.
DR TreeFam; TF336978; -.
DR PathwayCommons; Q711Q0; -.
DR SignaLink; Q711Q0; -.
DR BioGRID-ORCS; 118461; 7 hits in 1048 CRISPR screens.
DR ChiTaRS; C10orf71; human.
DR GenomeRNAi; 118461; -.
DR Pharos; Q711Q0; Tdark.
DR PRO; PR:Q711Q0; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q711Q0; protein.
DR Bgee; ENSG00000177354; Expressed in skeletal muscle tissue of rectus abdominis and 95 other tissues.
DR Genevisible; Q711Q0; HS.
DR GO; GO:0030018; C:Z disc; ISS:UniProtKB.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR InterPro; IPR027838; DUF4585.
DR Pfam; PF15232; DUF4585; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..1435
FT /note="Cardiac-enriched FHL2-interacting protein"
FT /id="PRO_0000282979"
FT REGION 109..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 120
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 470
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 816
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 693..719
FT /note="LNQKFFPGPLSPEEEDVFYSDSQSDFM -> THTHTHTHTHDHQHILSLFRS
FT IKSRRQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_024267"
FT VAR_SEQ 720..1435
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_024268"
FT VARIANT 208
FT /note="N -> K (in dbSNP:rs4838383)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_031441"
FT VARIANT 320
FT /note="R -> L (in dbSNP:rs56206226)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_061604"
FT VARIANT 461
FT /note="D -> A (in dbSNP:rs45554335)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_061605"
FT VARIANT 522
FT /note="V -> G (in dbSNP:rs61453891)"
FT /id="VAR_061606"
FT VARIANT 666
FT /note="H -> Q (in dbSNP:rs10857469)"
FT /id="VAR_031442"
FT VARIANT 698
FT /note="F -> S (in dbSNP:rs7921186)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_059608"
FT VARIANT 741
FT /note="D -> G (in dbSNP:rs11101093)"
FT /id="VAR_059609"
FT VARIANT 883
FT /note="D -> N (in dbSNP:rs12217617)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_059610"
FT VARIANT 958
FT /note="F -> Y (in dbSNP:rs10857470)"
FT /id="VAR_059611"
FT VARIANT 1084
FT /note="G -> A (in dbSNP:rs11101094)"
FT /id="VAR_059612"
FT VARIANT 1254
FT /note="V -> I (in dbSNP:rs11101095)"
FT /id="VAR_059613"
FT VARIANT 1337
FT /note="G -> S (in dbSNP:rs10857472)"
FT /id="VAR_059614"
FT CONFLICT 339
FT /note="A -> E (in Ref. 2; AL833265 and 4; AAI26414)"
FT /evidence="ECO:0000305"
FT CONFLICT 382
FT /note="R -> G (in Ref. 2; AL833265)"
FT /evidence="ECO:0000305"
FT CONFLICT 503
FT /note="L -> H (in Ref. 2; AL833265)"
FT /evidence="ECO:0000305"
FT CONFLICT 663
FT /note="M -> V (in Ref. 1; AK127811)"
FT /evidence="ECO:0000305"
FT CONFLICT 870..871
FT /note="PI -> RL (in Ref. 5; CAC85340)"
FT /evidence="ECO:0000305"
FT CONFLICT 1269
FT /note="A -> T (in Ref. 2; AL833265)"
FT /evidence="ECO:0000305"
FT CONFLICT 1281
FT /note="Q -> H (in Ref. 5; CAC85340)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1435 AA; 156477 MW; D120E1F57AF30CEE CRC64;
MMQGNKKCTD AFSDSSSIGS VLDDADREVS SLTDRAFRSL CISEDTSFHD SYLAVSPDIT
RQVFGTFHQR TVGHTQRKSG IWSQLPSQGT EHSGWAATFQ QLPKYVQGEE KYPKTSPPPT
PVQRRLEVPV SGLRSSNKPV SKVSTLIKSF DRTESQRCES RPTASKPPAL KNPPKFAPLP
ENSVNFCFDS AFLTVRRVPA EVSNTHQNSY QPGRKHGEQE SSKNPEMACH GSSSFLPAAN
DTATLCESKF PSPHHKPVTG EPGRGKGTFL HSENSAFESW NAHQPKLLER KDTAGTVPES
KAPKHYGDTT LLREPCPPER TVSPCQVQAS CSQEENRLAA GALSTSIPWG CRDPGAQVFA
VEGKAPSSQP DSQEKPAQPP WRKPKTGKKG KESLQDTLEE KTQTNQRGPP LYTKHNPQEQ
FSENNALDLP VEPNEHYDPP FNISKLLTPI IPSKHALDSA DSQPAERTPS PPGQLNGYQE
KEPSECQSRD SYKSKAPSLL FNLKDVRKRV KSTYSSSPLL KVLDEKTRGK VDGKQEPVSN
GVILPNGLEE SPPNELSKER PADDPTASHI NPQKDPTADP SEPSADSYLT LSTAPTIAKA
PFYVNGEAAE RSSYENKEVE GELEMGPAGS SWCPDSREHR PRKHLSLRLC NRDPEPGGAT
EKMKTHQLEN GLSRSVSQET EPEREAGLQN THLNQKFFPG PLSPEEEDVF YSDSQSDFMP
SLKGKAKFST SSSDQSFASF DDQQKMWFTE NQREDRRKDV SAGDSQKDEK ENVMRKDELQ
YCALSNGHAC LENRSQGEAL QRERESVSGG RTRKASAEEA NFRGSWIGEN KGTTFSQAKD
LTPSPSSASN RHMLFTIKDN TLRATPVIKP IMLPLLRTMS LEDSLSSGHK EEELPRPEWG
EDPGFCAPEN QDILGTSTPT NTRGTRVKCM ANEVMEDPGQ GSSMARMEAS QPAPKGNFPS
MPLVGEGDRV KAPPDAAPGL VASNCKSGSA DSGKLAAPWH IPTIALPEGD IEDQPPPWQP
ENCWEEQTPG FKSHFLSTPR AGPPGRRLVP SERANSPNPG SPGESSACSP AASNIWEESS
QAPGGPELLP EEPNQASPWA SSSPARVTRR EDLTHALVWE GGSDPLLELS AEDLRTLSPR
GSLLDVATSP AGTSGRLELP AQLERTASKP PAVPPKTEKA LRRAKKLASK RRKTDQAQEK
HGESQEGKPC PEDLEQTQQR PLCPRERPRH NFPVVRSLPP PVHRHSVSGF SEPVGRRPGG
PQSLTPLPAY PATQKVLQDP QSGEYFVFDL PLQVKIKTFY DPETGKYVKV SIPSSEGASP
EPPPPDALAA PYVLYPGFQP VPVTALMPLR CSSQLSAPTF LRQGPRASAA RARTQSVHES
GLQLDPGPHG DCTPHSAGQR PHGPPQSPGE EGVEAPGLGI ISTDDLEDFA TEGIS
