CEFIP_RAT
ID CEFIP_RAT Reviewed; 1422 AA.
AC M0RD54;
DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 39.
DE RecName: Full=Cardiac-enriched FHL2-interacting protein {ECO:0000303|PubMed:28717008};
GN Name=CEFIP {ECO:0000303|PubMed:28717008};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=28717008; DOI=10.1074/jbc.m117.786764;
RA Dierck F., Kuhn C., Rohr C., Hille S., Braune J., Sossalla S., Molt S.,
RA van der Ven P.F.M., Fuerst D.O., Frey N.;
RT "The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy
RT by modulating calcineurin signaling.";
RL J. Biol. Chem. 292:15180-15191(2017).
CC -!- FUNCTION: Plays an important role in cardiomyocyte hypertrophy via
CC activation of the calcineurin/NFAT signaling pathway.
CC {ECO:0000269|PubMed:28717008}.
CC -!- SUBUNIT: Interacts with FHL2. {ECO:0000250|UniProtKB:Q711Q0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC {ECO:0000269|PubMed:28717008}.
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DR EMBL; AC141211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006222177.1; XM_006222115.3.
DR RefSeq; XP_006222179.1; XM_006222117.3.
DR RefSeq; XP_006252819.1; XM_006252757.3.
DR RefSeq; XP_017443025.1; XM_017587536.1.
DR RefSeq; XP_017455785.1; XM_017600296.1.
DR RefSeq; XP_573855.2; XM_573855.6.
DR AlphaFoldDB; M0RD54; -.
DR STRING; 10116.ENSRNOP00000067550; -.
DR iPTMnet; M0RD54; -.
DR PhosphoSitePlus; M0RD54; -.
DR PaxDb; M0RD54; -.
DR Ensembl; ENSRNOT00000073370; ENSRNOP00000067550; ENSRNOG00000049942.
DR Ensembl; ENSRNOT00000098917; ENSRNOP00000081405; ENSRNOG00000049942.
DR GeneID; 498579; -.
DR KEGG; rno:498579; -.
DR CTD; 498579; -.
DR RGD; 1564899; RGD1564899.
DR eggNOG; ENOG502QVE3; Eukaryota.
DR GeneTree; ENSGT00730000111333; -.
DR HOGENOM; CLU_255771_0_0_1; -.
DR InParanoid; M0RD54; -.
DR OMA; HYSPPFN; -.
DR OrthoDB; 416362at2759; -.
DR PRO; PR:M0RD54; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000049942; Expressed in skeletal muscle tissue and 4 other tissues.
DR GO; GO:0030018; C:Z disc; IDA:UniProtKB.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IMP:UniProtKB.
DR InterPro; IPR027838; DUF4585.
DR Pfam; PF15232; DUF4585; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..1422
FT /note="Cardiac-enriched FHL2-interacting protein"
FT /id="PRO_0000444579"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 119
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q711Q0"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q711Q0"
FT MOD_RES 472
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q711Q0"
FT MOD_RES 815
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q711Q0"
SQ SEQUENCE 1422 AA; 155409 MW; 32C4B6B5A6F4E6F3 CRC64;
MQGNKKCADG FSDTSSIGSV LDEADREVSN LTDRAFRSLC ISEDTSFHDS DLALSPEITS
QVSGTFHQET VSHANRKSGI WSQLPSQGTE HSGWAATFQQ QPKYVQGEEK YPKNSPLPTP
VQRRLEVPIS GLRSSSKPIS KVSSLIRSFD RTEAQPCDSR PPPSKPPALK NTPKFAHPPE
SGVNFCFDSA FLTVRRVPAG VSSTHQSSHQ PCRAPGEPEP PTNPEIACHS SDSLLRAPDR
VAGSCEPRFP SPSLKPPKAE TGRGKEWISR GTFLHSENSA FESWDAHQPK LRERKDITET
TPESKAPKHY EDMPLLKEPY PAESKLSPCQ GRANCAQEEN RSPSGIQSTS GAWGARDSGS
QVFPVEGNAS QIDPQVKRNQ APWRKPKTGK GGTDGPHDAS EDKKQPNRKG LPLYSKLNPQ
GQLPENGVLD LPEESSDHYS SPFNISKLLT PIISTKHVLE TSDTQPVETS PSPPGQLNGY
QEKESSEAQS RDSYKSKAPS LLFNLKDVRK RVKSTYSPLP LLKGFDEKTR GKLDGKQEPL
SNGVTLPNGL EENPPTAELV KETLDDAPSV LHSSTQKDPA MDSRESFADS HPTFSSPSAS
SKTHFSINGE AAERNSHEKE EANGESEQGL SEGGWHPDSR ENLPRKHLSL KLCNRDSETG
QATEKMKPRQ LEKRLSRSIS QETEPEREMG FQNLPVSQKF SPGPLSPEEE DVFYSDSQSD
FTPCVQTKAK FSTSSSDQSF ASFEDQQKMW FTEGPREDGK SHVSLGDNQK DEKETEVEKE
EPQQCALHNG VEEHRQKETQ RKAQGVLGGR PRKASAEEVS VRGSWTGADK DTALSHAKDP
TPLPASTNKH RLFPIKDNTL RATPVIKPII LPLLRTVSSE DSLSGGHKEN ELPRQPWGED
AGGLGASESQ EMRNTPLSNS TPSTEQKCVV YEGVEEDPVH TAAQDETSQQ TRKGSFSFLP
LVEEGGKTKP PPDTADERLA HEKSRSADSG KLEAPQHIPT IALHSDDLED SPPSLPQHTC
WEEQGFKSHF LSAPRAGPSG RRPVPSEAAT SPNPSSLGGS STCSPAASSI WEDASQAAGE
HWQRQEPPGP GPWASPGPSG PTGLTRREDM TRGLTWEAEG SDPHLERLAD FRTLSPRGIF
LTGAAEKPEP SSLLEKAAGK PPAVPPKTEK ALRRAKKLAS KRRKSDQMSE KHTEAWEGKS
FTEDAQGTEQ RPVSPGKGPR PRFPEVRSLP PPTHRHSVSC GWEPAGRRPW GSQSLIPLPP
YPATQKVLQD PQSGQYFVFD MPLQVKIKTF YDPETGKYVK VSVPSSEEDP SEPPLQDALT
APYLLYPGFQ PVPVTSLMPL RCSSQLAAPT FLRQGSSHRP QSSQGARLQP PPERLGESAQ
HVSSAQRPRG PPLSPEEEGA EAPSLSIIST DDLEDFATEG VS
