CEH17_CAEEL
ID CEH17_CAEEL Reviewed; 237 AA.
AC G5EC89;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Homeobox protein ceh-17 {ECO:0000305};
GN Name=ceh-17 {ECO:0000312|WormBase:D1007.1};
GN ORFNames=D1007.1 {ECO:0000312|WormBase:D1007.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAF76229.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=10887091; DOI=10.1242/dev.127.15.3361;
RA Pujol N., Torregrossa P., Ewbank J.J., Brunet J.F.;
RT "The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal
RT growth in C. elegans.";
RL Development 127:3361-3371(2000).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20501595; DOI=10.1242/dev.040881;
RA Van Buskirk C., Sternberg P.W.;
RT "Paired and LIM class homeodomain proteins coordinate differentiation of
RT the C. elegans ALA neuron.";
RL Development 137:2065-2074(2010).
CC -!- FUNCTION: Probable transcription factor involved in postembryonic
CC differentiation of the ALA neuron, and regulation of genes that
CC contribute to behavioral quiescence, a sleep-like behavior mediated by
CC ALA (PubMed:20501595). Regulates its own expression and also that of
CC homeodomain ceh-14, together forming an autoregulatory loop in the ALA
CC neuron (PubMed:20501595). Involved in fasciculation-independent
CC longitudinal axonal navigation in many neurons (PubMed:10887091).
CC {ECO:0000269|PubMed:10887091, ECO:0000269|PubMed:20501595}.
CC -!- INTERACTION:
CC G5EC89; Q7K7J0: gei-18; NbExp=4; IntAct=EBI-2316478, EBI-2315822;
CC G5EC89; G5EC32: sorb-1; NbExp=4; IntAct=EBI-2316478, EBI-325337;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:10887091}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the L1 larval stage in five neurons
CC of the ring ganglia; a dorsal neuron, ALA, and four ventral SIA neurons
CC (SIADR, SIADL, SIAVR and SIAVL) (at protein level) (PubMed:10887091).
CC Earliest expression is at the end of gastrulation (PubMed:10887091).
CC Expressed at the comma stage, in two dorsal neurons in the head, and in
CC six cells on the ventral side of the head, just anterior to the
CC excretory pore (PubMed:10887091). {ECO:0000269|PubMed:10887091}.
CC -!- DISRUPTION PHENOTYPE: ALA and SIA axons exhibit outgrowth
CC abnormalities, failing to run along the lateral cord to the tail
CC (PubMed:10887091). ALA axons are shortened further in a vab-8 mutant
CC background (PubMed:10887091). Drastically reduced expression of let-
CC 23/EGFR and plc-3/PLCgamma in ALA neurons (PubMed:20501595). RNAi-
CC mediated knockdown causes severe defects in the ALA neuron in young
CC adults (PubMed:20501595). {ECO:0000269|PubMed:10887091,
CC ECO:0000269|PubMed:20501595}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AF272397; AAF76229.1; -; mRNA.
DR EMBL; BX284601; CCD67311.1; -; Genomic_DNA.
DR PIR; T30920; T30920.
DR RefSeq; NP_491393.1; NM_058992.3.
DR AlphaFoldDB; G5EC89; -.
DR SMR; G5EC89; -.
DR IntAct; G5EC89; 4.
DR STRING; 6239.D1007.1; -.
DR PaxDb; G5EC89; -.
DR EnsemblMetazoa; D1007.1.1; D1007.1.1; WBGene00000440.
DR GeneID; 172059; -.
DR KEGG; cel:CELE_D1007.1; -.
DR CTD; 172059; -.
DR WormBase; D1007.1; CE09036; WBGene00000440; ceh-17.
DR eggNOG; KOG0484; Eukaryota.
DR GeneTree; ENSGT00940000161147; -.
DR HOGENOM; CLU_1200736_0_0_1; -.
DR InParanoid; G5EC89; -.
DR OMA; MDYGGYF; -.
DR OrthoDB; 1014909at2759; -.
DR PhylomeDB; G5EC89; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000440; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:WormBase.
DR GO; GO:0048666; P:neuron development; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:WormBase.
DR GO; GO:0030516; P:regulation of axon extension; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR022135; Distal-less_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF12413; DLL_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Neurogenesis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..237
FT /note="Homeobox protein ceh-17"
FT /id="PRO_0000452000"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 58..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26704 MW; 285A42F859A9582B CRC64;
MMMEYGGYFS SSAVAQQSGD VPTTAPSAVT NSFFYTPQSH NIYHQYATPY LQSGRALTTA
HNTSSSSAGN STSSSSSSSN YRNTTHDSLQ AFFNTGLQYQ LYQKSQLIGS DTIQRTSSNV
LNGLPRSSLV GALCSTGGAP LNPAERRKQR RIRTTFTSGQ LKELERSFCE THYPDIYTRE
EIAMRIDLTE ARVQVWFQNR RAKYRKQEKI RRVKDEEEDP LKKEPGQISL EEIIDQI
