CEH51_CAEEL
ID CEH51_CAEEL Reviewed; 234 AA.
AC Q9U1R1;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Homeobox protein ceh-51 {ECO:0000303|PubMed:19605496};
GN Name=ceh-51 {ECO:0000312|WormBase:Y80D3A.3};
GN ORFNames=Y80D3A.3 {ECO:0000312|WormBase:Y80D3A.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=19605496; DOI=10.1242/dev.038307;
RA Broitman-Maduro G., Owraghi M., Hung W.W., Kuntz S., Sternberg P.W.,
RA Maduro M.F.;
RT "The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have
RT overlapping function in C. elegans mesoderm development.";
RL Development 136:2735-2746(2009).
CC -!- FUNCTION: Required for mesoderm development, including specification of
CC muscle and coelomocyte precursors. {ECO:0000269|PubMed:19605496}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU000682,
CC ECO:0000269|PubMed:19605496}. Note=Nuclear localization most obvious in
CC the 8 embryonic cells derived from the MS blastomere.
CC {ECO:0000269|PubMed:19605496}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the early embryo, in the mesodermal
CC lineage derived from the MS blastomere. {ECO:0000269|PubMed:19605496}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown on an hlh-1 mutant
CC background causes embryos to become paralyzed and arrested at the 2-
CC fold stage. {ECO:0000269|PubMed:19605496}.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR EMBL; BX284605; CAB60440.1; -; Genomic_DNA.
DR RefSeq; NP_507685.1; NM_075284.3.
DR AlphaFoldDB; Q9U1R1; -.
DR SMR; Q9U1R1; -.
DR IntAct; Q9U1R1; 18.
DR STRING; 6239.Y80D3A.3; -.
DR PaxDb; Q9U1R1; -.
DR EnsemblMetazoa; Y80D3A.3.1; Y80D3A.3.1; WBGene00013583.
DR GeneID; 180233; -.
DR KEGG; cel:CELE_Y80D3A.3; -.
DR UCSC; Y80D3A.3; c. elegans.
DR CTD; 180233; -.
DR WormBase; Y80D3A.3; CE24675; WBGene00013583; ceh-51.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000165097; -.
DR HOGENOM; CLU_1185963_0_0_1; -.
DR InParanoid; Q9U1R1; -.
DR PhylomeDB; Q9U1R1; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013583; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007501; P:mesodermal cell fate specification; IMP:WormBase.
DR GO; GO:0042694; P:muscle cell fate specification; IMP:WormBase.
DR GO; GO:0043282; P:pharyngeal muscle development; IMP:WormBase.
DR GO; GO:0060465; P:pharynx development; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..234
FT /note="Homeobox protein ceh-51"
FT /id="PRO_0000453377"
FT DNA_BIND 147..206
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 128..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 234 AA; 26540 MW; CF100121806D20A1 CRC64;
MSSSNYNINN GGDYYPLSSS NLNSTSAITN ATVMEYSTMP SSSPGSMSSS PAYPAAYQAP
SPCYVADPNQ LYYQQQLAHN GNDMLVQAHA QAYQAQCFAW FQQQYSQLSP SSFPHPMVAH
HAGFIPPPPS FLHHQHQQHP RAPSEKRRGA RTPFSDSQLY ALRTRFEQCD TIKVDERRKL
GAVIGLSPEQ IKIWFQNRRF KLRKEKYKQI KQDAVQQQKS AKEEAEEDQK HVIS
