CEH63_CAEEL
ID CEH63_CAEEL Reviewed; 152 AA.
AC A3FPJ2; A0A0K3ASL7;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Homeobox protein ceh-63 {ECO:0000303|PubMed:22207033};
GN Name=ceh-63 {ECO:0000312|WormBase:C02F12.10a};
GN ORFNames=C02F12.10 {ECO:0000312|WormBase:C02F12.10a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH CEH-14, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=22207033; DOI=10.1016/j.gene.2011.11.042;
RA Feng H., Reece-Hoyes J.S., Walhout A.J., Hope I.A.;
RT "A regulatory cascade of three transcription factors in a single specific
RT neuron, DVC, in Caenorhabditis elegans.";
RL Gene 494:73-84(2012).
CC -!- FUNCTION: Probable transcription factor, modulating expression of
CC helix-loop-helix protein mbr-1, perhaps acting in concert with homeobox
CC protein ceh-14 (PubMed:22207033). May play a minor role in axon
CC guidance in the DVC interneuron (PubMed:22207033).
CC {ECO:0000269|PubMed:22207033}.
CC -!- SUBUNIT: May interact with homeobox protein ceh-14.
CC {ECO:0000269|PubMed:22207033}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU000682,
CC ECO:0000269|PubMed:22207033}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:C02F12.10a};
CC IsoId=A3FPJ2-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:C02F12.10b};
CC IsoId=A3FPJ2-2; Sequence=VSP_061132;
CC -!- DEVELOPMENTAL STAGE: First expressed in comma stage embryos, continuing
CC into young adult hermaphrodites (PubMed:22207033). Expressed in the
CC single interneuron DVC, in the tail ganglion, from larval L3 stage and
CC throughout lifetime (PubMed:22207033). Expressed in the ut2 and ut3
CC cells in the uterus in young adults (PubMed:22207033).
CC {ECO:0000269|PubMed:22207033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284606; CCD62377.1; -; Genomic_DNA.
DR EMBL; BX284606; CTQ87023.1; -; Genomic_DNA.
DR RefSeq; NP_001123094.1; NM_001129622.1. [A3FPJ2-1]
DR RefSeq; NP_001300312.1; NM_001313383.1.
DR AlphaFoldDB; A3FPJ2; -.
DR SMR; A3FPJ2; -.
DR STRING; 6239.C02F12.10; -.
DR EPD; A3FPJ2; -.
DR PaxDb; A3FPJ2; -.
DR EnsemblMetazoa; C02F12.10a.1; C02F12.10a.1; WBGene00045215. [A3FPJ2-1]
DR EnsemblMetazoa; C02F12.10b.1; C02F12.10b.1; WBGene00045215. [A3FPJ2-2]
DR GeneID; 6418830; -.
DR KEGG; cel:CELE_C02F12.10; -.
DR UCSC; C02F12.10; c. elegans. [A3FPJ2-1]
DR CTD; 6418830; -.
DR WormBase; C02F12.10a; CE40680; WBGene00045215; ceh-63.
DR WormBase; C02F12.10b; CE50485; WBGene00045215; ceh-63.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00970000196641; -.
DR HOGENOM; CLU_1564299_0_0_1; -.
DR InParanoid; A3FPJ2; -.
DR OMA; AKNEYIC; -.
DR OrthoDB; 1583482at2759; -.
DR PhylomeDB; A3FPJ2; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00045215; Expressed in material anatomical entity and 5 other tissues.
DR ExpressionAtlas; A3FPJ2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..152
FT /note="Homeobox protein ceh-63"
FT /id="PRO_0000453378"
FT DNA_BIND 41..100
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 21..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..106
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061132"
SQ SEQUENCE 152 AA; 17912 MW; A66E0BB5D46F4067 CRC64;
MTSKTNMTSN KFAYDFFPWS NDTNSSQQIK NIKPPPKRSN RPTKRTTFTS EQVTLLELEF
AKNEYICKDR RGELAQTIEL TECQVKTWFQ NRRTKKRRCT SPLRKSMMKK SDERSPSPQN
PSSQHVQNLQ TFFHSWPSHF AYSLPSDQQN NV
