ID   CEI_HUMAN               Reviewed;         138 AA.
AC   Q86SI9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Protein CEI;
DE   AltName: Full=Coordinated expression to IRXA2 protein;
DE   Flags: Precursor;
GN   Name=C5orf38; Synonyms=CEI;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE
RP   SPLICING, AND TISSUE SPECIFICITY.
RC   TISSUE=Kidney;
RX   PubMed=16515847; DOI=10.1016/j.gene.2005.11.033;
RA   Wu Q., Tommerup N., Ming Wang S., Hansen L.;
RT   "A novel primate specific gene, CEI, is located in the homeobox gene IRXA2
RT   promoter in Homo sapiens.";
RL   Gene 371:167-173(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q86SI9; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-17872065, EBI-7062247;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=CEIa;
CC         IsoId=Q86SI9-1; Sequence=Displayed;
CC       Name=2; Synonyms=CEIb;
CC         IsoId=Q86SI9-2; Sequence=VSP_026648;
CC       Name=3; Synonyms=CEIc;
CC         IsoId=Q86SI9-3; Sequence=VSP_026649;
CC   -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in small intestine,
CC       testis and kidney, medium expressed in brain and heart and low
CC       expressed in colon; it could not be detected in liver, adrenal gland
CC       and pancreas. {ECO:0000269|PubMed:16515847}.
CC   -!- MISCELLANEOUS: According to PubMed:16515847, this gene is only
CC       represented in primates genome and it is highly conserved. Also found
CC       in bats (according to Ensembl).
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DR   EMBL; AY249324; AAP15241.1; -; Genomic_DNA.
DR   EMBL; AY249325; AAP15242.1; -; mRNA.
DR   EMBL; BC101608; AAI01609.1; -; mRNA.
DR   EMBL; BC101634; AAI01635.1; -; mRNA.
DR   RefSeq; NP_001281266.1; NM_001294337.1. [Q86SI9-3]
DR   RefSeq; NP_001293078.1; NM_001306149.1.
DR   RefSeq; NP_848664.1; NM_178569.3. [Q86SI9-1]
DR   RefSeq; XP_005248313.1; XM_005248256.3.
DR   AlphaFoldDB; Q86SI9; -.
DR   BioGRID; 127503; 1.
DR   IntAct; Q86SI9; 1.
DR   STRING; 9606.ENSP00000334267; -.
DR   iPTMnet; Q86SI9; -.
DR   BioMuta; C5orf38; -.
DR   PaxDb; Q86SI9; -.
DR   PRIDE; Q86SI9; -.
DR   ProteomicsDB; 69594; -. [Q86SI9-2]
DR   DNASU; 153571; -.
DR   GeneID; 153571; -.
DR   UCSC; uc003jdc.3; human. [Q86SI9-1]
DR   CTD; 153571; -.
DR   DisGeNET; 153571; -.
DR   GeneCards; C5orf38; -.
DR   HGNC; HGNC:24226; C5orf38.
DR   MIM; 610522; gene.
DR   neXtProt; NX_Q86SI9; -.
DR   PharmGKB; PA162380158; -.
DR   VEuPathDB; HostDB:ENSG00000186493; -.
DR   eggNOG; ENOG502TDUE; Eukaryota.
DR   HOGENOM; CLU_2793298_0_0_1; -.
DR   InParanoid; Q86SI9; -.
DR   OMA; QWHYRVH; -.
DR   OrthoDB; 1471538at2759; -.
DR   PhylomeDB; Q86SI9; -.
DR   TreeFam; TF338586; -.
DR   PathwayCommons; Q86SI9; -.
DR   SignaLink; Q86SI9; -.
DR   BioGRID-ORCS; 153571; 11 hits in 1052 CRISPR screens.
DR   ChiTaRS; C5orf38; human.
DR   GenomeRNAi; 153571; -.
DR   Pharos; Q86SI9; Tdark.
DR   PRO; PR:Q86SI9; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q86SI9; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..138
FT                   /note="Protein CEI"
FT                   /id="PRO_5000090517"
FT   VAR_SEQ         67..135
FT                   /note="RFVLSKHWGDDCYLTNRLWQDLKPPSHVENGQELRLAPPVQWALQVQGNQLQ
FT                   TAVLCLRMAPPEPAGSR -> S (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16515847"
FT                   /id="VSP_026649"
FT   VAR_SEQ         112..138
FT                   /note="VQGNQLQTAVLCLRMAPPEPAGSRQRI -> PKNLERVYVDTQVSASGDFLR
FT                   GRARGTAGPGGSGSGSPRGRGRLRRPGRSPGAAPSSVSRGRKEATQARSRARGRRGGAV
FT                   ARVCRPESRQRWARPTSSPGGLIRGRRKNGIEAFQ (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16515847"
FT                   /id="VSP_026648"
SQ   SEQUENCE   138 AA;  15091 MW;  2F84F3ED685B3CE3 CRC64;
     MVAPAARVFL RAVRAALTST VPDLLCLLAR GSPRGLASGR LPLAVHSAQH GPGSGAPWLR
     IARRALRFVL SKHWGDDCYL TNRLWQDLKP PSHVENGQEL RLAPPVQWAL QVQGNQLQTA
     VLCLRMAPPE PAGSRQRI