ID   CEL3A_XENLA             Reviewed;         462 AA.
AC   Q91579; Q6PF73;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=CUGBP Elav-like family member 3-A;
DE            Short=CELF-3A;
DE   AltName: Full=Bruno-like protein 1-A;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 3-A;
DE   AltName: Full=ELAV-type RNA-binding protein 1-A;
DE            Short=ETR-1-A;
DE   AltName: Full=RNA-binding protein BRUNOL-1-A;
DE   AltName: Full=Trinucleotide repeat-containing gene 4 protein A;
GN   Name=tnrc4-a; Synonyms=etr-1, etr1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=7601005; DOI=10.1242/dev.121.6.1927;
RA   Knecht A.K., Good P.J., Dawid I.B., Harland R.M.;
RT   "Dorsal-ventral patterning and differentiation of noggin-induced neural
RT   tissue in the absence of mesoderm.";
RL   Development 121:1927-1935(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that may be involved in the regulation of
CC       pre-mRNA alternative splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the nervous system.
CC       {ECO:0000269|PubMed:7601005}.
CC   -!- DEVELOPMENTAL STAGE: Not expressed maternally. Expressed throughout the
CC       neural plate at stage 13. Expressed in trigeminal ganglia at stage 20.
CC       Expressed in the spinal cord, hindbrain and ventral floor of the
CC       fore- and midbrain at early tailbud stages. Expressed throughout the
CC       CNS, including eyes, epiphyse, nasal pits, cranial ganglia and nerves
CC       at stage 38.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U16800; AAA81375.1; -; mRNA.
DR   EMBL; BC057704; AAH57704.1; -; mRNA.
DR   EMBL; BC072134; AAH72134.1; -; mRNA.
DR   RefSeq; NP_001079936.1; NM_001086467.1.
DR   AlphaFoldDB; Q91579; -.
DR   SMR; Q91579; -.
DR   DNASU; 379627; -.
DR   GeneID; 379627; -.
DR   KEGG; xla:379627; -.
DR   CTD; 379627; -.
DR   Xenbase; XB-GENE-6255196; celf3.L.
DR   OMA; NYPAYNA; -.
DR   OrthoDB; 1209165at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 379627; Expressed in brain and 8 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..462
FT                   /note="CUGBP Elav-like family member 3-A"
FT                   /id="PRO_0000295219"
FT   DOMAIN          7..88
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          95..175
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          377..455
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   CONFLICT        360
FT                   /note="L -> I (in Ref. 1; AAA81375)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   462 AA;  50431 MW;  51CBDE2BAF8C6BA1 CRC64;
     MKEPDAIKLF IGQIPRNLDE KDLKPIFEQF GKIYELTVIK DKFTGMHKGC AFLTYCARES
     ALKAQSALHE QKTLPGMNRP IQVKPADSES RGEDRKLFVG MLGKQQTDED VRRMFEPFGN
     IDECTVLRGP DGTSKGCAFV KFQTHTEAQA AINALHGSRT LPGASSSLVV KFADTEKERG
     LRRMQQVANQ LGMFSPIALQ FGAYSAYTQA VSDQLMQQQA ALVAAHSAYL NPMATMAAVQ
     MQQMATINPN GIIATPITQI NPITSSSGTS TPPTLTATQV SAIPATLGVN GYSAVPTQST
     VQPSSEAIYT NGLHPYPAQS PVAQLDPLQQ AYAGMQHYTA AYPAAYGLVS PAFTQPPAIL
     QQQPPQQQQQ REGPEGCNIF IYHLPQEFTD SEILQMFLPF GNVISAKVFV DRATNQSKCF
     GFVSFDNPGS AQAAIQAMNG FQIGMKRLKV QLKRPKDANR PY