ID   CEL3B_XENLA             Reviewed;         462 AA.
AC   Q7ZWM3;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=CUGBP Elav-like family member 3-B;
DE            Short=CELF3-B;
DE   AltName: Full=Bruno-like protein 1-B;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 3-B;
DE   AltName: Full=ELAV-type RNA-binding protein 1-B;
DE            Short=ETR-1-B;
DE   AltName: Full=RNA-binding protein BRUNOL-1-B;
DE   AltName: Full=Trinucleotide repeat-containing gene 4 protein B;
GN   Name=tnrc4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that may be involved in the regulation of
CC       pre-mRNA alternative splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR   EMBL; BC046942; AAH46942.1; -; mRNA.
DR   RefSeq; NP_001080695.1; NM_001087226.1.
DR   AlphaFoldDB; Q7ZWM3; -.
DR   SMR; Q7ZWM3; -.
DR   DNASU; 380387; -.
DR   GeneID; 380387; -.
DR   KEGG; xla:380387; -.
DR   CTD; 380387; -.
DR   Xenbase; XB-GENE-5796640; celf3.S.
DR   OrthoDB; 1209165at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 380387; Expressed in brain and 7 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..462
FT                   /note="CUGBP Elav-like family member 3-B"
FT                   /id="PRO_0000295220"
FT   DOMAIN          7..88
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          95..175
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          377..455
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   462 AA;  50373 MW;  A4B11DCB83E20EBB CRC64;
     MKEPDAIKLF IGQIPRNLDE KDLKPIFEQF GKIYELTVIK DKFTGMHKGC AFLTYCARES
     ALKAQSALHE QKTLPGMNRP IQVKPADSES RGEDRKLFVG MLGKQQTDED VRRMFETFGN
     IDECTVLRGP DGTSKGCAFV KFQTHTEAQA AINALHGSRT LPGASSSLVV KFADTEKERG
     LRRMQQVANQ LGMFSPIALQ FGAYSAYTQA VSDQLMQQQA ALVAAQSAYL NPMATMAAVQ
     MQQMATINPN GIIATPITQI NSITSSSGTS TPPTLTATPV SAIPATLGVN GYSAVPTQST
     VQPSSEAIYT NGLHPYPAQS PVAQLDPLQQ AYAGMQHYTA AYPAAYGLVS PAFTQPPAIL
     TQQPPQQQQQ REGPEGCNIF IYHLPQEFTD SEILQMFLPF GNVISAKVFV DRATNQSKCF
     GFVSFDNPGS AQAAIQSMNG FQIGMKRLKV QLKRPKDANR PY