CELF1_CHICK
ID CELF1_CHICK Reviewed; 489 AA.
AC Q5F3T7; Q8QGX1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=CUGBP Elav-like family member 1;
DE Short=CELF-1;
DE AltName: Full=Bruno-like protein 2;
DE AltName: Full=CUG triplet repeat RNA-binding protein 1;
DE Short=CUG-BP1;
DE AltName: Full=CUG-BP- and ETR-3-like factor 1;
DE AltName: Full=RNA-binding protein BRUNOL-2;
GN Name=CELF1; Synonyms=BRUL, CUGBP1; ORFNames=RCJMB04_7f23;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 96-423 (ISOFORM 1).
RA Suzuki H., Inoue K.;
RT "Bruno-like RNA binding protein.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=15830352; DOI=10.1002/dvdy.20382;
RA Ladd A.N., Stenberg M.G., Swanson M.S., Cooper T.A.;
RT "Dynamic balance between activation and repression regulates pre-mRNA
RT alternative splicing during heart development.";
RL Dev. Dyn. 233:783-793(2005).
CC -!- FUNCTION: RNA-binding protein that may be involved in pre-mRNA
CC alternative splicing, mRNA translation activation and stability.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15830352}. Cytoplasm
CC {ECO:0000269|PubMed:15830352}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5F3T7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5F3T7-2; Sequence=VSP_026790;
CC -!- DEVELOPMENTAL STAGE: Expressed in heart at embryonic day 14 (at protein
CC level). Expressed in heart at embryonic day 8.
CC {ECO:0000269|PubMed:15830352}.
CC -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR EMBL; AJ851563; CAH65197.1; -; mRNA.
DR EMBL; AB050497; BAB87829.1; -; mRNA.
DR RefSeq; NP_001012539.1; NM_001012521.1. [Q5F3T7-2]
DR AlphaFoldDB; Q5F3T7; -.
DR BMRB; Q5F3T7; -.
DR SMR; Q5F3T7; -.
DR STRING; 9031.ENSGALP00000013128; -.
DR PaxDb; Q5F3T7; -.
DR GeneID; 373923; -.
DR KEGG; gga:373923; -.
DR CTD; 10658; -.
DR VEuPathDB; HostDB:geneid_373923; -.
DR eggNOG; KOG0144; Eukaryota.
DR InParanoid; Q5F3T7; -.
DR OrthoDB; 1209165at2759; -.
DR PhylomeDB; Q5F3T7; -.
DR PRO; PR:Q5F3T7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12631; RRM1_CELF1_2_Bruno; 1.
DR CDD; cd12634; RRM2_CELF1_2; 1.
DR CDD; cd12638; RRM3_CELF1_2; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR034196; CELF1/2_RRM1.
DR InterPro; IPR034198; CELF1/2_RRM2.
DR InterPro; IPR034199; CELF1/2_RRM3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 3.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Cytoplasm; mRNA processing; mRNA splicing;
KW Nucleus; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..489
FT /note="CUGBP Elav-like family member 1"
FT /id="PRO_0000295184"
FT DOMAIN 16..99
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 108..188
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 404..482
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VAR_SEQ 230..233
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15642098"
FT /id="VSP_026790"
FT CONFLICT 189
FT /note="Q -> P (in Ref. 2; BAB87829)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="G -> S (in Ref. 2; BAB87829)"
FT /evidence="ECO:0000305"
FT CONFLICT 350
FT /note="G -> V (in Ref. 2; BAB87829)"
FT /evidence="ECO:0000305"
FT CONFLICT 419
FT /note="D -> V (in Ref. 2; BAB87829)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 52156 MW; 6E9F44FF755876F5 CRC64;
MNGTLDHPDQ PDLDAIKMFV GQVPRSWCEK DLRELFEQYG AVYEINVLRD RSQNPPQSKG
CCFVTFYTRK AALEAQNALH NMKILPGMHH PIQMKPADSE KNNAVEDRKL FIGMISKKCN
ENDIRVMFSP FGQIEECRIL RGPDGLSRGC AFVTFTTRAM AQTAIKAMHQ AQTMEGCSSP
IVVKFADTQK DKEQKRIAQQ LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAA
ASSGNLNTLS SLHPMGGLNA MQLQNLAALA AAASAAQNTP SGTAALTSSS SPLSVLTSSA
GSSPSSSGSS SVNPMASLGA LQTLAGATAG LNVSSLAGMA ALNGGLGSGG LSNGTGSTME
ALTQAYSGIQ QYAAAALPTL YNQSLLTQQS IGAAGSQKEG PEGANLFIYH LPQEFGDQDL
LQMFMPFGNV VSAKVFIDKQ TNLSKCFGFV SYDNPVSAQA AIQSMNGFQI GMKRLKVQLK
RSKNDSKPY
