CELF2_DANRE
ID CELF2_DANRE Reviewed; 514 AA.
AC Q6P0B1; Q4U0V4; Q4U0V6; Q8QGX2; Q90ZV0;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=CUGBP Elav-like family member 2;
DE Short=CELF-2;
DE AltName: Full=Bruno-like protein 3;
DE AltName: Full=CUG triplet repeat RNA-binding protein 2;
DE Short=CUG-BP2;
DE AltName: Full=CUG-BP- and ETR-3-like factor 2;
DE AltName: Full=ELAV-type RNA-binding protein 3;
DE Short=ETR-3;
DE AltName: Full=RNA-binding protein BRUNOL-3;
GN Name=celf2; Synonyms=cugbp2, etr3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Suzuki H., Inoue K.;
RT "Elav-type ribonucleoprotein-3.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
RA Choi D.-K., Sakaki Y.;
RT "Isolation and molecular characterization of zebrafish Napor.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
RC STRAIN=AB;
RA Takahashi N., Dawid I.B.;
RT "Splicing variants of zebrafish Napor.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pharyngula;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding protein implicated in the regulation of several
CC post-transcriptional events. May be involved in pre-mRNA alternative
CC splicing, mRNA translation repression and stability (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95319}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q7T2T1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6P0B1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P0B1-2; Sequence=VSP_026817;
CC Name=3;
CC IsoId=Q6P0B1-3; Sequence=VSP_026819, VSP_026820, VSP_026821;
CC Name=4; Synonyms=Short;
CC IsoId=Q6P0B1-4; Sequence=VSP_026818, VSP_026820;
CC Name=5;
CC IsoId=Q6P0B1-5; Sequence=VSP_026817, VSP_026820;
CC -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR EMBL; AB050496; BAB87828.1; -; mRNA.
DR EMBL; AF321194; AAK52851.1; -; mRNA.
DR EMBL; DQ021474; AAY43159.1; -; mRNA.
DR EMBL; DQ021476; AAY43161.1; -; mRNA.
DR EMBL; AL935165; CAH68907.2; -; Genomic_DNA.
DR EMBL; AL935165; CAH68908.2; -; Genomic_DNA.
DR EMBL; BX511190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065686; AAH65686.1; -; mRNA.
DR RefSeq; NP_919382.1; NM_194401.1. [Q6P0B1-2]
DR RefSeq; XP_005164919.1; XM_005164862.3. [Q6P0B1-3]
DR RefSeq; XP_005164921.1; XM_005164864.3. [Q6P0B1-4]
DR AlphaFoldDB; Q6P0B1; -.
DR BMRB; Q6P0B1; -.
DR SMR; Q6P0B1; -.
DR STRING; 7955.ENSDARP00000108480; -.
DR PaxDb; Q6P0B1; -.
DR Ensembl; ENSDART00000017443; ENSDARP00000025183; ENSDARG00000002131. [Q6P0B1-3]
DR Ensembl; ENSDART00000128368; ENSDARP00000112156; ENSDARG00000002131. [Q6P0B1-1]
DR GeneID; 373117; -.
DR KEGG; dre:373117; -.
DR CTD; 10659; -.
DR ZFIN; ZDB-GENE-030826-35; celf2.
DR eggNOG; KOG0144; Eukaryota.
DR GeneTree; ENSGT00940000155461; -.
DR InParanoid; Q6P0B1; -.
DR OrthoDB; 1209165at2759; -.
DR PhylomeDB; Q6P0B1; -.
DR PRO; PR:Q6P0B1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000002131; Expressed in granulocyte and 25 other tissues.
DR ExpressionAtlas; Q6P0B1; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12631; RRM1_CELF1_2_Bruno; 1.
DR CDD; cd12634; RRM2_CELF1_2; 1.
DR CDD; cd12638; RRM3_CELF1_2; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR034196; CELF1/2_RRM1.
DR InterPro; IPR034198; CELF1/2_RRM2.
DR InterPro; IPR034199; CELF1/2_RRM3.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 3.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; mRNA processing; Nucleus;
KW Reference proteome; Repeat; Repressor; RNA-binding.
FT CHAIN 1..514
FT /note="CUGBP Elav-like family member 2"
FT /id="PRO_0000295194"
FT DOMAIN 44..127
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 136..216
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 429..507
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VAR_SEQ 1..28
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|Ref.1, ECO:0000303|Ref.2"
FT /id="VSP_026817"
FT VAR_SEQ 1..22
FT /note="MRYPSTANSAVSMRSTEELLLS -> MTSSYNLDFLPEMMVDGRLLSAGERI
FT (in isoform 4)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_026818"
FT VAR_SEQ 1
FT /note="M -> MLEHSSELGFVPSVCVDSM (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_026819"
FT VAR_SEQ 279..323
FT /note="Missing (in isoform 3, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|Ref.2, ECO:0000303|Ref.3"
FT /id="VSP_026820"
FT VAR_SEQ 362..365
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_026821"
SQ SEQUENCE 514 AA; 54552 MW; 82805F8ECA8ABC77 CRC64;
MRYPSTANSA VSMRSTEELL LSNGTAGKMN GALEHSDQPD PDAIKMFVGQ IPRSWSEKEL
KELFEPYGAV YQINILRDRS QNPPQSKGCC FVTFYTRKAA LEAQNALHNI KTLTGMHHPI
QMKPADSEKS NAVEDRKLFI GMVSKKCNEN DIRVMFSPYG QIEECRILRG PDGLSRGCAF
VTFSTRAMAQ NAIKAMHQSQ TMEGCSSPMV VKFADTQKDK EQRRLQQQLA QQMQQLNSAS
AWGSLTGLTG LTPQYLALLQ QATSSSNLGA FSGIQQMAGM NALQLQNLAT LAAAAAAAQS
SASPSTASAL TSSTGSLGAL ASPAGSTANS SAAMGSLGSL GTLQGLAGAT VGLNNINALA
GSVNSMAALN GGLGSTGLSN GSAGPMDALT QAYSGIQQYA AAALPTLYSQ SLLQQQSAAG
SQKEGPEGAN LFIYHLPQEF GDQDILQMFM PFGNVVSAKV FIDKQTNLSK CFGFVSYDNP
VSAQAAIQAM NGFQIGMKRL KVQLKRSKND SKPY
