ID   CELF2_XENTR             Reviewed;         513 AA.
AC   A4IIM2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=CUGBP Elav-like family member 2;
DE            Short=CELF-2;
DE   AltName: Full=Bruno-like protein 3;
DE   AltName: Full=CUG triplet repeat RNA-binding protein 2;
DE            Short=CUG-BP2;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 2;
DE   AltName: Full=ELAV-type RNA-binding protein 3;
DE            Short=ETR-3;
DE   AltName: Full=RNA-binding protein BRUNOL-3;
GN   Name=celf2; Synonyms=brunol3, cugbp2, etr3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein implicated in the regulation of several
CC       post-transcriptional events. May be involved in pre-mRNA alternative
CC       splicing, mRNA translation repression and stability (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95319}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7T2T1}.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR   EMBL; BC136076; AAI36077.1; -; mRNA.
DR   RefSeq; NP_001096417.1; NM_001102947.1.
DR   AlphaFoldDB; A4IIM2; -.
DR   BMRB; A4IIM2; -.
DR   SMR; A4IIM2; -.
DR   STRING; 8364.ENSXETP00000047617; -.
DR   PaxDb; A4IIM2; -.
DR   DNASU; 100125022; -.
DR   Ensembl; ENSXETT00000047614; ENSXETP00000047614; ENSXETG00000021992.
DR   GeneID; 100125022; -.
DR   KEGG; xtr:100125022; -.
DR   CTD; 10659; -.
DR   Xenbase; XB-GENE-963640; celf2.
DR   eggNOG; KOG0144; Eukaryota.
DR   InParanoid; A4IIM2; -.
DR   OrthoDB; 1209165at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021992; Expressed in brain and 7 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12631; RRM1_CELF1_2_Bruno; 1.
DR   CDD; cd12634; RRM2_CELF1_2; 1.
DR   CDD; cd12638; RRM3_CELF1_2; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034196; CELF1/2_RRM1.
DR   InterPro; IPR034198; CELF1/2_RRM2.
DR   InterPro; IPR034199; CELF1/2_RRM3.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat; Repressor;
KW   RNA-binding.
FT   CHAIN           1..513
FT                   /note="CUGBP Elav-like family member 2"
FT                   /id="PRO_0000295196"
FT   DOMAIN          35..118
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          127..207
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          428..506
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   513 AA;  54774 MW;  B4D8DA6777D1C530 CRC64;
     MMVDSRLLVS DRINGTTNKM NGALDHSDQP DPDAIKMFVG QIPRSWSEKE LKDLFEPYGA
     VYQINVLRDR SQNPPQSKGC CFVTFYTRKA ALEAQNALHN IKTLPGMHHP IQMKPADSEK
     SNAVEDRKLF IGMVSKKCNE NDIRVMFSPF GQIEECRILR GPDGLSRGCA FVTFSTRAMA
     QNAIKAMHQS QTMEGCSSPI VVKFADTQKD KEQRRLQQQL AQQMQQLNTA TWGNLTGLGA
     LTPQYLALLQ QATSSSNLGA FSGIQQMAGM NALQLQNLAT LAAAAAAAQT SATTTNANPL
     STTTSALGAL TSPVAASTAN SSAGAAMNSL TSLGTLQGLA GATVGLNNIN ALAGTVNIAQ
     MLSGMAALNG GLGATGLTNG TAGTMDALTQ AYSGIQQYAA AALPTLYSQS LLQQQSAAGS
     QKEGPEGANL FIYHLPQEFG DQDILQMFMP FGNVISAKVF IDKQTNLSKC FGFVSYDNPV
     SAQAAIQAMN GFQIGMKRLK VQLKRSKNDS KPY