ID   CELF3_BOVIN             Reviewed;         461 AA.
AC   Q08E07;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=CUGBP Elav-like family member 3;
DE            Short=CELF-3;
DE   AltName: Full=Bruno-like protein 1;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 3;
DE   AltName: Full=ELAV-type RNA-binding protein 1;
DE            Short=ETR-1;
DE   AltName: Full=RNA-binding protein BRUNOL-1;
DE   AltName: Full=Trinucleotide repeat-containing gene 4 protein;
GN   Name=CELF3; Synonyms=TNRC4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in the regulation of pre-mRNA
CC       alternative splicing. Mediates exon inclusion and/or exclusion in pre-
CC       mRNA that are subject to tissue-specific and developmentally regulated
CC       alternative splicing. Specifically activates exon 5 inclusion of
CC       cardiac isoforms of TNNT2 during heart remodeling at the juvenile to
CC       adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to
CC       muscle-specific splicing enhancer (MSE) intronic sites flanking the
CC       alternative exon 5 of TNNT2 pre-mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR   EMBL; BC123480; AAI23481.1; -; mRNA.
DR   RefSeq; NP_001070313.1; NM_001076845.1.
DR   AlphaFoldDB; Q08E07; -.
DR   SMR; Q08E07; -.
DR   STRING; 9913.ENSBTAP00000033756; -.
DR   PaxDb; Q08E07; -.
DR   PRIDE; Q08E07; -.
DR   Ensembl; ENSBTAT00000033848; ENSBTAP00000033756; ENSBTAG00000019131.
DR   GeneID; 513347; -.
DR   KEGG; bta:513347; -.
DR   CTD; 11189; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019131; -.
DR   VGNC; VGNC:27168; CELF3.
DR   eggNOG; KOG0146; Eukaryota.
DR   GeneTree; ENSGT00940000154716; -.
DR   HOGENOM; CLU_015367_0_1_1; -.
DR   InParanoid; Q08E07; -.
DR   OMA; NYPAYNA; -.
DR   OrthoDB; 1209165at2759; -.
DR   TreeFam; TF314924; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000019131; Expressed in retina and 49 other tissues.
DR   ExpressionAtlas; Q08E07; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0097322; F:7SK snRNA binding; IEA:Ensembl.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR   GO; GO:0098781; P:ncRNA transcription; IEA:Ensembl.
DR   GO; GO:0030575; P:nuclear body organization; IEA:Ensembl.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..461
FT                   /note="CUGBP Elav-like family member 3"
FT                   /id="PRO_0000295197"
FT   DOMAIN          7..88
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          95..175
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          376..454
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          345..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..360
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  50092 MW;  16193D875F81DD28 CRC64;
     MKEPDAIKLF VGQIPRHLEE KDLKPIFEQF GRIFELTVIK DKYTGLHKGC AFLTYCARDS
     ALKAQSALHE QKTLPGMNRP IQVKPADSES RGEDRKLFVG MLGKQQTDED VRKMFEPFGT
     IDECTVLRGP DGTSKGCAFV KFQTHAEAQA AINTLHSSRT LPGASSSLVV KFADTEKERG
     LRRMQQVATQ LGMFSPIALQ FGAYSAYTQA LMQQQAALVA AHSAYLSPMA TMAAVQMQHM
     AAINANGLIA TPITPSSGTS TPPAIAATPV SAIPAALGVN GYSPVPTQPT GQPAPDALYP
     NGVHPYPAQS PAAPVDPLQQ AYAGMQHYTA YPAAYSLVAP AFPQPPALVA QQPPPPPQQQ
     QQQQQQQQQR EGPDGCNIFI YHLPQEFTDS EILQMFVPFG HVISAKVFVD RATNQSKCFG
     FVSFDNPASA QAAIQAMNGF QIGMKRLKVQ LKRPKDANRP Y