ID   CELF3_DANRE             Reviewed;         452 AA.
AC   Q9IBD1; Q6P953;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=CUGBP Elav-like family member 3;
DE            Short=CELF-3;
DE   AltName: Full=Bruno-like protein 1;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 3;
DE   AltName: Full=ELAV-type RNA-binding protein 1;
DE            Short=ETR-1;
DE   AltName: Full=RNA-binding protein BRUNOL-1;
DE   AltName: Full=Trinucleotide repeat-containing gene 4 protein;
GN   Name=celf3; Synonyms=etr1, tnrc4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10781958; DOI=10.1016/s0925-4773(00)00270-7;
RA   Suzuki H., Maegawa S., Nishibu T., Sugiyama T., Yasuda K., Inoue K.;
RT   "Vegetal localization of the maternal mRNA encoding an EDEN-BP/Bruno-like
RT   protein in zebrafish.";
RL   Mech. Dev. 93:205-209(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that may be involved in the regulation of
CC       pre-mRNA alternative splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR   EMBL; AB032725; BAA95118.1; -; mRNA.
DR   EMBL; BX248499; CAK04904.1; -; Genomic_DNA.
DR   EMBL; BC060923; AAH60923.1; -; mRNA.
DR   RefSeq; NP_571569.2; NM_131494.2.
DR   AlphaFoldDB; Q9IBD1; -.
DR   SMR; Q9IBD1; -.
DR   STRING; 7955.ENSDARP00000039628; -.
DR   PaxDb; Q9IBD1; -.
DR   Ensembl; ENSDART00000039629; ENSDARP00000039628; ENSDARG00000034668.
DR   Ensembl; ENSDART00000193951; ENSDARP00000153718; ENSDARG00000034668.
DR   GeneID; 57922; -.
DR   KEGG; dre:57922; -.
DR   CTD; 57922; -.
DR   ZFIN; ZDB-GENE-000501-2; celf3a.
DR   eggNOG; KOG0146; Eukaryota.
DR   GeneTree; ENSGT00940000154716; -.
DR   HOGENOM; CLU_015367_0_1_1; -.
DR   InParanoid; Q9IBD1; -.
DR   OMA; HAYQGMA; -.
DR   OrthoDB; 1209165at2759; -.
DR   PhylomeDB; Q9IBD1; -.
DR   TreeFam; TF314924; -.
DR   PRO; PR:Q9IBD1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000034668; Expressed in camera-type eye and 23 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..452
FT                   /note="CUGBP Elav-like family member 3"
FT                   /id="PRO_0000295218"
FT   DOMAIN          7..88
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          94..174
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          367..445
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   CONFLICT        197
FT                   /note="S -> N (in Ref. 1; BAA95118)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   452 AA;  48939 MW;  5965BFD2560ABA99 CRC64;
     MKEADAIKLF IGQIPRNLEE KDLKPIFEQF GKIYELTVIK DKYTGMHKGC AFLTYCARES
     ALKAQNALHE QKTLPGMNRP IQVKPADSEG RGDRKLFVGM LGKQLSDADV RKMFEPFGSI
     EECTVLRGPD GASKGCAFVK YQSNAEAQAA ISALHGSRTL PGASSSLVVK FADTEKERGI
     RRMQQVASQL GVISPMSLHL GAYNAYTQAL VQQQALVAQS AYLSPVATVA AVQMQQLAAL
     NPSSIIATPI ASITPSSGTS TPPTIAATPV PALPPPIAVN SYPPVPAAPN GQSASEALYT
     NGVHPYQAQS PALDPLQQAY TGMQHYTATY PAAYGLVGQP FPHQPTLVAQ QPQQPQQLQQ
     REGPEGCNIF IYHLPQEFTD SEMLQMFLPF GNVISAKVFV DRATNQSKCF GFVSFDNPAS
     AQAAIQAMNG FQIGMKRLKV QLKRPKDANR PY