ID   CELF4_DANRE             Reviewed;         520 AA.
AC   Q6DGV1;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=CUGBP Elav-like family member 4;
DE            Short=CELF-4;
DE   AltName: Full=Bruno-like protein 4;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 4;
DE   AltName: Full=RNA-binding protein BRUNOL-4;
GN   Name=celf4; Synonyms=brunol4; ORFNames=zgc:92761;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that may be implicated in the regulation
CC       of pre-mRNA alternative splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR   EMBL; BC076238; AAH76238.1; -; mRNA.
DR   RefSeq; NP_001002562.1; NM_001002562.2.
DR   AlphaFoldDB; Q6DGV1; -.
DR   SMR; Q6DGV1; -.
DR   STRING; 7955.ENSDARP00000122295; -.
DR   PaxDb; Q6DGV1; -.
DR   Ensembl; ENSDART00000081510; ENSDARP00000075951; ENSDARG00000070045.
DR   GeneID; 436835; -.
DR   KEGG; dre:436835; -.
DR   CTD; 56853; -.
DR   ZFIN; ZDB-GENE-040718-300; celf4.
DR   eggNOG; KOG0146; Eukaryota.
DR   GeneTree; ENSGT00940000158673; -.
DR   InParanoid; Q6DGV1; -.
DR   OrthoDB; 1209165at2759; -.
DR   PhylomeDB; Q6DGV1; -.
DR   PRO; PR:Q6DGV1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000070045; Expressed in brain and 9 other tissues.
DR   ExpressionAtlas; Q6DGV1; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..520
FT                   /note="CUGBP Elav-like family member 4"
FT                   /id="PRO_0000295225"
FT   DOMAIN          47..128
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          135..215
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          435..513
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   520 AA;  55726 MW;  6D1BD397080B57FC CRC64;
     MATLTNGQVD AAVHGGAAST NGLVNGISHT HSPASCATIP MKDHDAIKLF IGQIPRNLDE
     KDLRPLFEEF GKIYELTVLK DRFTGMHKGC AFLTYCARES ALKAQTALHE QKTLPGMNRP
     IQVKPADSES RGEDRKLFVG MLNKQQCEDD VRRLFESFGS IEECTILRGP DGNSKGCAFV
     KYSTHAEAQA AISALHGSQT MPGASSSLVV KFADTDKERT IRRMQQMAGQ MGIFNPMALQ
     FGAYGAYAQV QQQAALMASV GQGGYLSPMA AFAAAQMQHM ATINGLPGAP MTPTSGGSTP
     PGITAPTVTS IPSPISVNGF TGLPPPQANG QAPAEAMFTN GIHPYPVLQE VVFREDSEKG
     GLGVAQRSCF GVQGSCFLSS LSEAQSPTAA DPLQQAYAGV QQYAAFPAAY GQISQAFPQP
     PPIIPQQQRE GPEGCNLFIY HLPQEFGDGE LMQMFLPFGN VISSKVFVDR ATNQSKCFGF
     VSFDNPGSAQ AAIQSMNGFQ IGMKRLKVQL KRPKDANRPY