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CELF4_XENTR
ID   CELF4_XENTR             Reviewed;         424 AA.
AC   Q0V9L3;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=CUGBP Elav-like family member 4;
DE            Short=CELF-4;
DE   AltName: Full=Bruno-like protein 4;
DE   AltName: Full=CUG-BP- and ETR-3-like factor 4;
DE   AltName: Full=RNA-binding protein BRUNOL-4;
GN   Name=celf4; Synonyms=brunol4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that may be implicated in the regulation
CC       of pre-mRNA alternative splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR   EMBL; BC121490; AAI21491.1; -; mRNA.
DR   RefSeq; NP_001072378.1; NM_001078910.1.
DR   AlphaFoldDB; Q0V9L3; -.
DR   SMR; Q0V9L3; -.
DR   DNASU; 779831; -.
DR   GeneID; 779831; -.
DR   KEGG; xtr:779831; -.
DR   CTD; 56853; -.
DR   Xenbase; XB-GENE-5873699; celf4.
DR   InParanoid; Q0V9L3; -.
DR   OrthoDB; 1209165at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020486; Expressed in brain and 6 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..424
FT                   /note="CUGBP Elav-like family member 4"
FT                   /id="PRO_0000295226"
FT   DOMAIN          47..128
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          342..417
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          8..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  45250 MW;  0DC7C1FEFBD74E2F CRC64;
     MYIKMATVAN GQPDNSSLSS NPTGHMNGLT HSPGGAATIP MKDHDAIKLF IGQIPRNLDE
     KDLKPLFEEF GKIYELTVLK DRFTGMHKGC AFLTYCERES ALKAQSALHE QKTLPGMNRP
     IQVKPADSES RGGCAFVKYS SHAEAQAAIN ALHGSQTMPG ASSSLVVKFA DTDKERTMRR
     MQQMAGQMGM FNPMAIQFGA YGAYAQALMQ QQAAIMASVA QGGYLNPMAA FAAAQMQQMA
     ALNMNGLAAA PMTPTSGGST PPGITAPAVP SIPSPIGVNG FTGIPAQANG QPAAEAVFAN
     GIHPYPAQSP TAADPLQQAY AGVQQYAAAY PAAYGQISQA FPQPPPMIPQ QQREGPEGCN
     LFIYHLPQEF GDAELMQMFL PFGFVSFDNP ASAQAAIQAM NGFQIGMKRL KVQLKRPKDA
     NRPY
 
 
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