CELF6_MOUSE
ID CELF6_MOUSE Reviewed; 460 AA.
AC Q7TN33; Q8BJ35;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=CUGBP Elav-like family member 6;
DE Short=CELF-6;
DE AltName: Full=Bruno-like protein 6;
DE AltName: Full=CUG-BP- and ETR-3-like factor 6;
DE AltName: Full=RNA-binding protein BRUNOL-6;
GN Name=Celf6; Synonyms=Brunol6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA
CC alternative splicing. Mediates exon inclusion and/or exclusion in pre-
CC mRNA that are subject to tissue-specific and developmentally regulated
CC alternative splicing. Specifically activates exon 5 inclusion of TNNT2
CC in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes
CC also exon exclusion of INSR pre-mRNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TN33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TN33-2; Sequence=VSP_026849;
CC -!- SIMILARITY: Belongs to the CELF/BRUNOL family. {ECO:0000305}.
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DR EMBL; AK034216; BAC28635.1; -; mRNA.
DR EMBL; BC052406; AAH52406.1; -; mRNA.
DR EMBL; BC057083; AAH57083.1; -; mRNA.
DR CCDS; CCDS23251.1; -. [Q7TN33-1]
DR CCDS; CCDS90585.1; -. [Q7TN33-2]
DR RefSeq; NP_001298021.1; NM_001311092.1.
DR RefSeq; NP_780444.2; NM_175235.3. [Q7TN33-1]
DR RefSeq; XP_006511609.1; XM_006511546.2.
DR AlphaFoldDB; Q7TN33; -.
DR SMR; Q7TN33; -.
DR STRING; 10090.ENSMUSP00000034840; -.
DR iPTMnet; Q7TN33; -.
DR PhosphoSitePlus; Q7TN33; -.
DR MaxQB; Q7TN33; -.
DR PaxDb; Q7TN33; -.
DR PRIDE; Q7TN33; -.
DR ProteomicsDB; 281372; -. [Q7TN33-1]
DR ProteomicsDB; 281373; -. [Q7TN33-2]
DR DNASU; 76183; -.
DR Ensembl; ENSMUST00000034840; ENSMUSP00000034840; ENSMUSG00000032297. [Q7TN33-1]
DR Ensembl; ENSMUST00000121266; ENSMUSP00000113196; ENSMUSG00000032297. [Q7TN33-2]
DR GeneID; 76183; -.
DR KEGG; mmu:76183; -.
DR UCSC; uc009pxx.1; mouse. [Q7TN33-1]
DR CTD; 60677; -.
DR MGI; MGI:1923433; Celf6.
DR VEuPathDB; HostDB:ENSMUSG00000032297; -.
DR eggNOG; KOG0146; Eukaryota.
DR GeneTree; ENSGT00940000154201; -.
DR HOGENOM; CLU_015367_0_1_1; -.
DR InParanoid; Q7TN33; -.
DR PhylomeDB; Q7TN33; -.
DR TreeFam; TF314924; -.
DR BioGRID-ORCS; 76183; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q7TN33; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q7TN33; protein.
DR Bgee; ENSMUSG00000032297; Expressed in arcuate nucleus of hypothalamus and 87 other tissues.
DR ExpressionAtlas; Q7TN33; baseline and differential.
DR Genevisible; Q7TN33; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISO:MGI.
DR GO; GO:0099153; P:synaptic transmission, serotonergic; IMP:MGI.
DR GO; GO:0071625; P:vocalization behavior; IMP:MGI.
DR CDD; cd12632; RRM1_CELF3_4_5_6; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR034648; CELF3/4/5/6_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; mRNA processing; Nucleus;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..460
FT /note="CUGBP Elav-like family member 6"
FT /id="PRO_0000295230"
FT DOMAIN 46..127
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 134..214
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 375..453
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..115
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_026849"
SQ SEQUENCE 460 AA; 48206 MW; D032BA0FFE8C67C6 CRC64;
MAAAPGGSAP PAGPSPRLAF STADSGGGMS GLNPGPAVPM KDHDAIKLFV GQIPRGLDEQ
DLKPLFEEFG RIYELTVLKD RLTGLHKGCA FLTYCARDSA LKAQSALHEQ KTLPGMNRPI
QVKPAASEGR GEDRKLFVGM LGKQQGEEDV RRLFQPFGHI EECTVLRSPD GTSKGCAFVK
FGSQGEAQAA IQGLHGSRTM TGASSSLVVK LADTDRERAL RRMQQMAGQL GAFHPAPLPL
GACGAYTTAI LQHQAALLAA AQGPGLGQVA AVAAQMQHVA AFSLVAAPLL PAAANTSPGG
NGPGALPGLP APMGVNGFGS LTPQSNGQPG SDTLYNNGVS PYPAAYPSAY APASTAFSQQ
PSALPQQQRE GPEGCNLFIY HLPQEFGDAE LIQTFLPFGA VVSAKVFVDR ATNQSKCFGF
VSFDNPTSAQ TAIQAMNGFQ IGMKRLKVQL KRPKDANRPY
