ID   CELR_THEFU              Reviewed;         340 AA.
AC   O87590;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=HTH-type transcriptional regulator CelR;
GN   Name=celR;
OS   Thermobifida fusca (Thermomonospora fusca).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=2021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ER1;
RX   PubMed=10224066; DOI=10.1074/jbc.274.19.13127;
RA   Spiridonov N.A., Wilson D.B.;
RT   "Characterization and cloning of celR, a transcriptional regulator of
RT   cellulase genes from Thermomonospora fusca.";
RL   J. Biol. Chem. 274:13127-13132(1999).
CC   -!- FUNCTION: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA-3' in
CC       the upstream regions of cellulase genes; these operator sequences are
CC       modulated by cellobiose.
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DR   EMBL; AF086819; AAC42987.1; -; Genomic_DNA.
DR   RefSeq; WP_011291385.1; NZ_ONLN01000144.1.
DR   AlphaFoldDB; O87590; -.
DR   SMR; O87590; -.
DR   OMA; AWRHVIL; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..340
FT                   /note="HTH-type transcriptional regulator CelR"
FT                   /id="PRO_0000107937"
FT   DOMAIN          1..61
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        9..28
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   340 AA;  36864 MW;  BBE82B8EC77E7A2E CRC64;
     MERRRRPTLE MVAALAGVGR GTVSRVINGS DQVSPATREA VKRAIKELGY VPNRAARTLV
     TRRTDTVALV VSENNQKLFA EPFYAGIVLG VGVALSERGF QFVLATGRSG IEHERLGGYL
     AGQHVDGVLL LSLHRDDPLP QMLDEAGVPY VYGGRPLGVP EEQVSYVDID NIGGGRQATQ
     RLIETGHRRI ATIAGPQDMV AGVERLQGYR EALLAAGMEY DETLVSYGDF TYDSGVAAMR
     ELLDRAPDVD AVFAASDLMG LAALRVLRAS GRRVPEDVAV VGYDDSTVAE HAEPPMTSVN
     QPTELMGREM ARLLVDRITG ETTEPVRLVL ETHLMVRESG