ID   CEM1_CONIM              Reviewed;          83 AA.
AC   A0A125S9D9;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Conotoxin Im22.1 {ECO:0000305};
DE   AltName: Full=Conopeptide im005 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17663.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is XXII (C-C-C-C-C-C-C-C).
CC       {ECO:0000305}.
CC   -!- PTM: Contain 4 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin E superfamily. {ECO:0000305}.
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DR   EMBL; KT377399; AME17663.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9D9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..26
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000450996"
FT   CHAIN           27..83
FT                   /note="Conotoxin Im22.1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179751"
SQ   SEQUENCE   83 AA;  9708 MW;  27902E6C256102F7 CRC64;
     MMMRVFIAMF FLLALVEAGW PRLYDKNCKK NILRTYCSNK ICGEATKNTN GELQCTMYCR
     CANGCFRGQY IDWPNQQTNL LFC