ID   CEMA_RANMC              Reviewed;         229 AA.
AC   Q4FGG7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Chloroplast envelope membrane protein;
GN   Name=cemA {ECO:0000255|HAMAP-Rule:MF_01308};
OS   Ranunculus macranthus (Large buttercup).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Ranunculoideae;
OC   Ranunculeae; Ranunculus.
OX   NCBI_TaxID=334596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15944438; DOI=10.1093/molbev/msi191;
RA   Leebens-Mack J., Raubeson L.A., Cui L., Kuehl J.V., Fourcade M.H.,
RA   Chumley T.W., Boore J.L., Jansen R.K., dePamphilis C.W.;
RT   "Identifying the basal angiosperm node in chloroplast genome phylogenies:
RT   sampling one's way out of the Felsenstein zone.";
RL   Mol. Biol. Evol. 22:1948-1963(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17573971; DOI=10.1186/1471-2164-8-174;
RA   Raubeson L.A., Peery R., Chumley T.W., Dziubek C., Fourcade H.M.,
RA   Boore J.L., Jansen R.K.;
RT   "Comparative chloroplast genomics: analyses including new sequences from
RT   the angiosperms Nuphar advena and Ranunculus macranthus.";
RL   BMC Genomics 8:174-174(2007).
CC   -!- FUNCTION: May be involved in proton extrusion. Indirectly promotes
CC       efficient inorganic carbon uptake into chloroplasts.
CC       {ECO:0000255|HAMAP-Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000255|HAMAP-Rule:MF_01308}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; DQ069364; AAZ03808.1; -; Genomic_DNA.
DR   EMBL; DQ359689; ABC70768.1; -; Genomic_DNA.
DR   RefSeq; YP_001004198.1; NC_008796.1.
DR   AlphaFoldDB; Q4FGG7; -.
DR   GeneID; 4712142; -.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Chloroplast; Hydrogen ion transport; Ion transport; Membrane; Plastid;
KW   Plastid inner membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..229
FT                   /note="Chloroplast envelope membrane protein"
FT                   /id="PRO_0000293531"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   229 AA;  26757 MW;  74353950AFACDF48 CRC64;
     MQKKKAFNPL LYLTSIVFLS WSISFSFKKS MESLVIHWWN AEQSEVFLND IQEKSALEKF
     IELEELLFLD EMIKESPDIH IQKLRIGIHK ETIQLVKMYN EGHIHTILNF LTNIISFAIL
     SVFYILGNEQ LVILNSWVRE FIYNLSDTIK AFCILLLTDL CIGFHSPHGW ELMIGSVYKD
     FGFSHNNQII SGLVSTFPVI LDTIFKYLIF RYLNRVSPSL VVIYHSIND