CEND_HUMAN
ID CEND_HUMAN Reviewed; 149 AA.
AC Q8N111; Q9NYM6;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Cell cycle exit and neuronal differentiation protein 1;
DE AltName: Full=BM88 antigen;
GN Name=CEND1; Synonyms=BM88;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBUNIT.
RC TISSUE=Brain;
RX PubMed=11311134; DOI=10.1042/bj3550715;
RA Gaitanou M., Buanne P., Pappa C., Georgopoulou N., Mamalaki A., Tirone F.,
RA Matsas R.;
RT "Cloning, expression and localization of human BM88 shows that it maps to
RT chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and
RT tumorigenesis.";
RL Biochem. J. 355:715-724(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Papadodima O., Mamalaki A., Matsas R.;
RT "Structural and functional characterization of human BM88.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in neuronal differentiation.
CC {ECO:0000250|UniProtKB:Q9JKC6}.
CC -!- SUBUNIT: Homodimer (PubMed:11311134). Interacts with AHI1 (By
CC similarity). {ECO:0000250|UniProtKB:Q9JKC6,
CC ECO:0000269|PubMed:11311134}.
CC -!- INTERACTION:
CC Q8N111; Q96JG8: MAGED4; NbExp=3; IntAct=EBI-946825, EBI-721864;
CC Q8N111; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-946825, EBI-11956541;
CC Q8N111; A0A142I5B9; Xeno; NbExp=3; IntAct=EBI-946825, EBI-20625235;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Neuron specific. {ECO:0000269|PubMed:11311134}.
CC -!- SIMILARITY: Belongs to the CEND1 family. {ECO:0000305}.
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DR EMBL; AF235030; AAF60309.1; -; mRNA.
DR EMBL; AY304478; AAP57306.1; -; Genomic_DNA.
DR EMBL; AK074547; BAC11051.1; -; mRNA.
DR EMBL; BC034732; AAH34732.1; -; mRNA.
DR CCDS; CCDS7714.1; -.
DR RefSeq; NP_057648.2; NM_016564.3.
DR AlphaFoldDB; Q8N111; -.
DR BioGRID; 119438; 7.
DR IntAct; Q8N111; 7.
DR STRING; 9606.ENSP00000328336; -.
DR GlyGen; Q8N111; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8N111; -.
DR PhosphoSitePlus; Q8N111; -.
DR BioMuta; CEND1; -.
DR DMDM; 28376966; -.
DR jPOST; Q8N111; -.
DR MassIVE; Q8N111; -.
DR MaxQB; Q8N111; -.
DR PaxDb; Q8N111; -.
DR PeptideAtlas; Q8N111; -.
DR PRIDE; Q8N111; -.
DR ProteomicsDB; 71513; -.
DR Antibodypedia; 22655; 124 antibodies from 30 providers.
DR DNASU; 51286; -.
DR Ensembl; ENST00000330106.5; ENSP00000328336.4; ENSG00000184524.6.
DR GeneID; 51286; -.
DR KEGG; hsa:51286; -.
DR MANE-Select; ENST00000330106.5; ENSP00000328336.4; NM_016564.4; NP_057648.2.
DR UCSC; uc001lrh.2; human.
DR CTD; 51286; -.
DR DisGeNET; 51286; -.
DR GeneCards; CEND1; -.
DR HGNC; HGNC:24153; CEND1.
DR HPA; ENSG00000184524; Tissue enriched (brain).
DR MIM; 608213; gene.
DR neXtProt; NX_Q8N111; -.
DR OpenTargets; ENSG00000184524; -.
DR PharmGKB; PA145149163; -.
DR VEuPathDB; HostDB:ENSG00000184524; -.
DR eggNOG; ENOG502SGTV; Eukaryota.
DR GeneTree; ENSGT00390000012831; -.
DR HOGENOM; CLU_1748972_0_0_1; -.
DR InParanoid; Q8N111; -.
DR OMA; FFDNMKP; -.
DR OrthoDB; 1547337at2759; -.
DR PhylomeDB; Q8N111; -.
DR TreeFam; TF336209; -.
DR PathwayCommons; Q8N111; -.
DR SignaLink; Q8N111; -.
DR BioGRID-ORCS; 51286; 51 hits in 1056 CRISPR screens.
DR GenomeRNAi; 51286; -.
DR Pharos; Q8N111; Tbio.
DR PRO; PR:Q8N111; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N111; protein.
DR Bgee; ENSG00000184524; Expressed in right hemisphere of cerebellum and 154 other tissues.
DR Genevisible; Q8N111; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0021686; P:cerebellar granular layer maturation; IBA:GO_Central.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IBA:GO_Central.
DR GO; GO:0021941; P:negative regulation of cerebellar granule cell precursor proliferation; IEA:Ensembl.
DR GO; GO:0021933; P:radial glia guided migration of cerebellar granule cell; IBA:GO_Central.
DR InterPro; IPR020162; Cend1.
DR PANTHER; PTHR36683; PTHR36683; 1.
DR Pfam; PF15677; CEND1; 1.
PE 1: Evidence at protein level;
KW Differentiation; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..149
FT /note="Cell cycle exit and neuronal differentiation protein
FT 1"
FT /id="PRO_0000064951"
FT TOPO_DOM 1..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..149
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVI4"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVI4"
FT CONFLICT 116
FT /note="P -> S (in Ref. 1; AAF60309)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 149 AA; 14954 MW; 8251BCDD5A10E7BE CRC64;
MESRGKSASS PKPDTKVPQV TTEAKVPPAA DGKAPLTKPS KKEAPAEKQQ PPAAPTTAPA
KKTSAKADPA LLNNHSNLKP APTVPSSPDA TPEPKGPGDG AEEDEAASGG PGGRGPWSCE
NFNPLLVAGG VAVAAIALIL GVAFLVRKK
