CEND_MOUSE
ID CEND_MOUSE Reviewed; 149 AA.
AC Q9JKC6; Q9DBA0;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cell cycle exit and neuronal differentiation protein 1;
DE AltName: Full=BM88 antigen;
GN Name=Cend1; Synonyms=Bm88;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11311134; DOI=10.1042/bj3550715;
RA Gaitanou M., Buanne P., Pappa C., Georgopoulou N., Mamalaki A., Tirone F.,
RA Matsas R.;
RT "Cloning, expression and localization of human BM88 shows that it maps to
RT chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and
RT tumorigenesis.";
RL Biochem. J. 355:715-724(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 43-61 AND 99-114, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP FUNCTION, INTERACTION WITH AHI1, AND TISSUE SPECIFICITY.
RX PubMed=23658157; DOI=10.1523/jneurosci.0119-13.2013;
RA Weng L., Lin Y.F., Li A.L., Wang C.E., Yan S., Sun M., Gaertig M.A.,
RA Mitha N., Kosaka J., Wakabayashi T., Xu X., Tang B., Li S., Li X.J.;
RT "Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated
RT neuronal differentiation.";
RL J. Neurosci. 33:8172-8184(2013).
CC -!- FUNCTION: Involved in neuronal differentiation.
CC {ECO:0000269|PubMed:23658157}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with AHI1
CC (PubMed:23658157). {ECO:0000250|UniProtKB:Q8N111,
CC ECO:0000269|PubMed:23658157}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, including hypothalamus,
CC brainstem, and hippocampus. Expression is high in 1-month-old mouse
CC brain and then declines in mature mouse brains at the age of 3 and 7
CC months. {ECO:0000269|PubMed:23658157}.
CC -!- SIMILARITY: Belongs to the CEND1 family. {ECO:0000305}.
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DR EMBL; AF243130; AAF62099.1; -; mRNA.
DR EMBL; AK005092; BAB23812.1; -; mRNA.
DR EMBL; AK079045; BAC37512.1; -; mRNA.
DR EMBL; BC023032; AAH23032.1; -; mRNA.
DR CCDS; CCDS22012.1; -.
DR RefSeq; NP_067291.1; NM_021316.4.
DR RefSeq; XP_006536280.1; XM_006536217.3.
DR AlphaFoldDB; Q9JKC6; -.
DR SMR; Q9JKC6; -.
DR BioGRID; 208316; 4.
DR STRING; 10090.ENSMUSP00000118591; -.
DR iPTMnet; Q9JKC6; -.
DR PhosphoSitePlus; Q9JKC6; -.
DR MaxQB; Q9JKC6; -.
DR PaxDb; Q9JKC6; -.
DR PeptideAtlas; Q9JKC6; -.
DR PRIDE; Q9JKC6; -.
DR ProteomicsDB; 281460; -.
DR Antibodypedia; 22655; 124 antibodies from 30 providers.
DR Ensembl; ENSMUST00000084436; ENSMUSP00000081476; ENSMUSG00000060240.
DR Ensembl; ENSMUST00000124444; ENSMUSP00000118591; ENSMUSG00000060240.
DR Ensembl; ENSMUST00000137488; ENSMUSP00000123334; ENSMUSG00000060240.
DR Ensembl; ENSMUST00000164387; ENSMUSP00000131085; ENSMUSG00000060240.
DR GeneID; 57754; -.
DR KEGG; mmu:57754; -.
DR UCSC; uc009kkx.1; mouse.
DR CTD; 51286; -.
DR MGI; MGI:1929898; Cend1.
DR VEuPathDB; HostDB:ENSMUSG00000060240; -.
DR eggNOG; ENOG502SGTV; Eukaryota.
DR GeneTree; ENSGT00390000012831; -.
DR HOGENOM; CLU_1748972_0_0_1; -.
DR InParanoid; Q9JKC6; -.
DR OMA; FFDNMKP; -.
DR OrthoDB; 1547337at2759; -.
DR PhylomeDB; Q9JKC6; -.
DR TreeFam; TF336209; -.
DR BioGRID-ORCS; 57754; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Cend1; mouse.
DR PRO; PR:Q9JKC6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JKC6; protein.
DR Bgee; ENSMUSG00000060240; Expressed in pontine nuclear group and 183 other tissues.
DR Genevisible; Q9JKC6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0031982; C:vesicle; ISO:MGI.
DR GO; GO:0007628; P:adult walking behavior; IMP:MGI.
DR GO; GO:0021686; P:cerebellar granular layer maturation; IMP:MGI.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
DR GO; GO:0021941; P:negative regulation of cerebellar granule cell precursor proliferation; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
DR GO; GO:0021933; P:radial glia guided migration of cerebellar granule cell; IMP:MGI.
DR InterPro; IPR020162; Cend1.
DR PANTHER; PTHR36683; PTHR36683; 1.
DR Pfam; PF15677; CEND1; 1.
PE 1: Evidence at protein level;
KW Differentiation; Direct protein sequencing; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..149
FT /note="Cell cycle exit and neuronal differentiation protein
FT 1"
FT /id="PRO_0000064952"
FT TOPO_DOM 1..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..149
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVI4"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVI4"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 117
FT /note="W -> R (in Ref. 2; BAB23812)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 149 AA; 14987 MW; 88B252ED5DD1EE9B CRC64;
MESRGKSASS PKPDTKVPQA TAEAKATPAA DGKAPLTKPV KKDTQAEKQE QAAAPGPAAT
KKTPAKADPV LLNNHSNLKP APTVPAAPSS PDATSEPKGP GDGAEEDESN TGGRGPWPCE
NLTPLLVAGG VAVATIALIL GVAFLARKK
