CEND_PIG
ID CEND_PIG Reviewed; 140 AA.
AC Q29026;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Cell cycle exit and neuronal differentiation protein 1;
DE AltName: Full=BM88 antigen;
GN Name=CEND1; Synonyms=BM88;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 7-17, FUNCTION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=7775480; DOI=10.1074/jbc.270.23.14201;
RA Mamalaki A., Boutou E., Hurel C., Patsavoudi E., Tzartos S., Matsas R.;
RT "The BM88 antigen, a novel neuron-specific molecule, enhances the
RT differentiation of mouse neuroblastoma cells.";
RL J. Biol. Chem. 270:14201-14208(1995).
CC -!- FUNCTION: Involved in neuronal differentiation.
CC {ECO:0000269|PubMed:7775480}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with AHI1 (By
CC similarity). {ECO:0000250|UniProtKB:Q8N111,
CC ECO:0000250|UniProtKB:Q9JKC6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}. Endomembrane system {ECO:0000305};
CC Single-pass type IV membrane protein {ECO:0000305}. Note=Associated
CC with the plasma membrane and the membranes of intracellular organelles.
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Found in the spinal cord, cerebellum and cerebrum,
CC where it is localized in neurons. {ECO:0000269|PubMed:7775480}.
CC -!- DEVELOPMENTAL STAGE: Appears during early brain development where it
CC increases with age to give high levels in the mature animal.
CC -!- SIMILARITY: Belongs to the CEND1 family. {ECO:0000305}.
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DR EMBL; X82027; CAA57549.1; -; mRNA.
DR PIR; A57544; A57544.
DR RefSeq; NP_999031.1; NM_213866.1.
DR RefSeq; XP_005652821.1; XM_005652764.2.
DR RefSeq; XP_013845179.1; XM_013989725.1.
DR RefSeq; XP_013845182.1; XM_013989728.1.
DR AlphaFoldDB; Q29026; -.
DR STRING; 9823.ENSSSCP00000013655; -.
DR PaxDb; Q29026; -.
DR PeptideAtlas; Q29026; -.
DR Ensembl; ENSSSCT00000014040; ENSSSCP00000013655; ENSSSCG00000012845.
DR Ensembl; ENSSSCT00025018142; ENSSSCP00025007318; ENSSSCG00025013654.
DR Ensembl; ENSSSCT00030048062; ENSSSCP00030021677; ENSSSCG00030034726.
DR Ensembl; ENSSSCT00035108735; ENSSSCP00035047151; ENSSSCG00035079487.
DR Ensembl; ENSSSCT00040047779; ENSSSCP00040019975; ENSSSCG00040035572.
DR Ensembl; ENSSSCT00045023044; ENSSSCP00045015913; ENSSSCG00045013486.
DR Ensembl; ENSSSCT00050046306; ENSSSCP00050019127; ENSSSCG00050034481.
DR Ensembl; ENSSSCT00055006042; ENSSSCP00055004734; ENSSSCG00055003128.
DR Ensembl; ENSSSCT00060055310; ENSSSCP00060023628; ENSSSCG00060040822.
DR Ensembl; ENSSSCT00065049808; ENSSSCP00065021552; ENSSSCG00065036544.
DR Ensembl; ENSSSCT00070055142; ENSSSCP00070046793; ENSSSCG00070027503.
DR GeneID; 396876; -.
DR KEGG; ssc:396876; -.
DR CTD; 51286; -.
DR VGNC; VGNC:86544; CEND1.
DR eggNOG; ENOG502SGTV; Eukaryota.
DR GeneTree; ENSGT00390000012831; -.
DR HOGENOM; CLU_1748972_0_0_1; -.
DR InParanoid; Q29026; -.
DR OMA; FFDNMKP; -.
DR TreeFam; TF336209; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000012845; Expressed in prefrontal cortex and 26 other tissues.
DR Genevisible; Q29026; SS.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0021686; P:cerebellar granular layer maturation; IBA:GO_Central.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IBA:GO_Central.
DR GO; GO:0021941; P:negative regulation of cerebellar granule cell precursor proliferation; IEA:Ensembl.
DR GO; GO:0021933; P:radial glia guided migration of cerebellar granule cell; IBA:GO_Central.
DR InterPro; IPR020162; Cend1.
DR PANTHER; PTHR36683; PTHR36683; 1.
DR Pfam; PF15677; CEND1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Differentiation; Direct protein sequencing; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..140
FT /note="Cell cycle exit and neuronal differentiation protein
FT 1"
FT /id="PRO_0000064953"
FT TOPO_DOM 1..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVI4"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVI4"
SQ SEQUENCE 140 AA; 13968 MW; 1F4F6C2D2FEC6DFD CRC64;
MESRGRSANS PKADAKATTE ARAPPAVDGK VPSAKKQEAQ KAEKQEPPAA PTLPPAKKTS
ALLDNHSNLK PAPAAPSSPD AAPEPKGPGD GAEEAEAPSG GPGGRGPCPF ENLNPLLVAG
GIAMAAAALI LGVVFLARKK
