CENL2_HUMAN
ID CENL2_HUMAN Reviewed; 272 AA.
AC P0DPI3;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 18-JUL-2018, sequence version 1.
DT 03-AUG-2022, entry version 19.
DE RecName: Full=Centromere protein V-like protein 2 {ECO:0000305};
DE AltName: Full=Centromere protein V pseudogene 2 {ECO:0000312|HGNC:HGNC:43879};
GN Name=CENPVL2 {ECO:0000312|HGNC:HGNC:43879};
GN Synonyms=CENPVP2 {ECO:0000312|HGNC:HGNC:43879};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU01239};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000255|PROSITE-
CC ProRule:PRU01239};
CC -!- SIMILARITY: Belongs to the Gfa family. {ECO:0000305}.
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DR EMBL; AC234030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS87744.1; -.
DR AlphaFoldDB; P0DPI3; -.
DR SMR; P0DPI3; -.
DR jPOST; P0DPI3; -.
DR MassIVE; P0DPI3; -.
DR PeptideAtlas; P0DPI3; -.
DR PRIDE; P0DPI3; -.
DR Ensembl; ENST00000634648.1; ENSP00000489328.1; ENSG00000283093.1.
DR MANE-Select; ENST00000602548.2; ENSP00000489273.1; NM_001355277.1; NP_001342206.1.
DR MANE-Select; ENST00000634648.1; ENSP00000489328.1; NM_001355278.1; NP_001342207.1.
DR GeneCards; CENPVL2; -.
DR HGNC; HGNC:43879; CENPVL2.
DR HPA; ENSG00000283093; Tissue enhanced (brain).
DR neXtProt; NX_P0DPI3; -.
DR OpenTargets; ENSG00000223591; -.
DR VEuPathDB; HostDB:ENSG00000283093; -.
DR GeneTree; ENSGT00390000003183; -.
DR OMA; GTITHVH; -.
DR Pharos; P0DPI3; Tdark.
DR PRO; PR:P0DPI3; -.
DR Proteomes; UP000005640; Chromosome X.
DR Bgee; ENSG00000283093; Expressed in cortical plate and 21 other tissues.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR006913; CENP-V/GFA.
DR InterPro; IPR011057; Mss4-like_sf.
DR Pfam; PF04828; GFA; 1.
DR SUPFAM; SSF51316; SSF51316; 1.
DR PROSITE; PS51891; CENP_V_GFA; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..272
FT /note="Centromere protein V-like protein 2"
FT /id="PRO_0000444698"
FT DOMAIN 133..246
FT /note="CENP-V/GFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="structural"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT BINDING 139
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="structural"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT BINDING 157
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT BINDING 159
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT BINDING 162
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT BINDING 201
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="structural"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
FT BINDING 204
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="structural"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01239"
SQ SEQUENCE 272 AA; 29887 MW; 46BE2B55BF5CA500 CRC64;
MGRVRNRATA QRRRRKRPGD PPAACAAIAV TGASRAQCPR VQVGVGSHAA AKRWLGRWRR
KRRWRRVRKA GPRDLLPSAP TPDPPGPAPS PKDLDLGAQR ERWETFRKLR GLSCEGAAKV
LLDTFEYPGL VHHTGGCHCG AVRFAVWAPA DLRVVDCSCR LCRKKQHRHF LVPASRFTLL
QGAESIVTYR SNTHPALHSF CSRCGVQSFH AAVSDPRVYG VAPHCLDEGT VRSVVIEEVG
GGDPGEEAAE EHKAIHKTSS QSAPACPREQ EQ
