ID   CENNB_XENLA             Reviewed;         348 AA.
AC   Q5U4T8;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Centromere protein N-B;
DE            Short=CENP-N-B;
GN   Name=cenpn-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-N/CHL4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH84956.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC084956; AAH84956.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001088558.1; NM_001095089.1.
DR   AlphaFoldDB; Q5U4T8; -.
DR   SMR; Q5U4T8; -.
DR   DNASU; 495435; -.
DR   GeneID; 495435; -.
DR   KEGG; xla:495435; -.
DR   CTD; 495435; -.
DR   Xenbase; XB-GENE-6253842; cenpn.L.
DR   OrthoDB; 1145159at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 495435; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   InterPro; IPR007902; Chl4/mis15/CENP-N.
DR   Pfam; PF05238; CENP-N; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Centromere protein N-B"
FT                   /id="PRO_0000249499"
SQ   SEQUENCE   348 AA;  39713 MW;  127B02D6A3452462 CRC64;
     MDEWLAEFIK RTILKLPFSE TATILKTWGF LTESELQTFT LRYPKEVTAT EVVRFCEARN
     ATLDHAAALD LVFNHAYSNK KTWTVYQMSK RLESENDLFD ASEFKLQFKK SIHAVSKNVT
     INFKEFGEAL WIRIAWGTHN SRPNQYKATF AVYHSQTPYV FITGLGKACQ PLMCQALVIA
     SKYSQIQEME LKSRCLESLK DIVFKRFNQP FSSHHSKPHE KALTPNIVDP RVTYENMREK
     DRVYHLTCET FGEGPLPKLE LASYKLETMF KADSAMSGNL TAVNEPFRCV VKFSSPHLLE
     AIRSLAPAGI AEAPISTLLS CIPHKARNSF KITEKRSMHP SSSQPTNV