CENP1_HUMAN
ID CENP1_HUMAN Reviewed; 187 AA.
AC B2RD01;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Putative CENPB DNA-binding domain-containing protein 1;
GN Name=CENPBD1P {ECO:0000312|HGNC:HGNC:28272}; Synonyms=CENPBD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000255|PROSITE-ProRule:PRU00583}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AK315352; BAG37748.1; -; mRNA.
DR EMBL; AC092143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009263; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_659476.2; NM_145039.3.
DR AlphaFoldDB; B2RD01; -.
DR SMR; B2RD01; -.
DR BioGRID; 124980; 2.
DR STRING; 9606.ENSP00000393854; -.
DR iPTMnet; B2RD01; -.
DR PhosphoSitePlus; B2RD01; -.
DR BioMuta; CENPBD1; -.
DR MassIVE; B2RD01; -.
DR PaxDb; B2RD01; -.
DR PeptideAtlas; B2RD01; -.
DR PRIDE; B2RD01; -.
DR ProteomicsDB; 3425; -.
DR DNASU; 92806; -.
DR GeneID; 92806; -.
DR UCSC; uc002fpr.4; human.
DR CTD; 92806; -.
DR DisGeNET; 92806; -.
DR GeneCards; CENPBD1; -.
DR HGNC; HGNC:28272; CENPBD1P.
DR neXtProt; NX_B2RD01; -.
DR VEuPathDB; HostDB:ENSG00000177946; -.
DR eggNOG; KOG3105; Eukaryota.
DR HOGENOM; CLU_018294_6_2_1; -.
DR InParanoid; B2RD01; -.
DR OMA; RFKECHC; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; B2RD01; -.
DR PathwayCommons; B2RD01; -.
DR SignaLink; B2RD01; -.
DR BioGRID-ORCS; 92806; 8 hits in 1076 CRISPR screens.
DR GenomeRNAi; 92806; -.
DR Pharos; B2RD01; Tdark.
DR PRO; PR:B2RD01; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; B2RD01; protein.
DR Genevisible; B2RD01; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 5: Uncertain;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..187
FT /note="Putative CENPB DNA-binding domain-containing protein
FT 1"
FT /id="PRO_0000394661"
FT DOMAIN 13..64
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 78..155
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DNA_BIND 40..60
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 111..148
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT CONFLICT 168
FT /note="T -> I (in Ref. 3; BC009263)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 187 AA; 21052 MW; AB2EC1EF82BED323 CRC64;
MPGERPTDAT VIPSAKRERK AITLDLKLEV LRRFEAGEKL SQIAKALDLA ISTVATIRDS
KEKIKASSQI ATPLRASRLT RHRSAVMESM EQLLSLWLED QSQPNATLSA AIVQEKAEFD
DLQREHGEGS QTERFHASQG WLVRFKECHC LPHFKMNSAA PSNKDMYTEM LKSIIEEGEY
TPQVSLT
