CENPA_CANAL
ID CENPA_CANAL Reviewed; 211 AA.
AC Q59LN9; A0A1D8PJ32;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Histone H3-like centromeric protein CSE4;
DE AltName: Full=CENP-A homolog;
GN Name=CSE4; OrderedLocusNames=CAALFM_C300860WA; ORFNames=CaO19.6163;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Histone H3-like variant which exclusively replaces
CC conventional H3 in the nucleosome core of centromeric chromatin at the
CC inner plate of the kinetochore. Required for recruitment and assembly
CC of kinetochore proteins, mitotic progression and chromosome
CC segregation. May serve as an epigenetic mark that propagates centromere
CC identity through replication and cell division (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the core kinetochore. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC Note=Localizes exclusively in the kinetochore domain of centromeres.
CC {ECO:0000250}.
CC -!- PTM: Ubiquitinated. Is degraded through ubiquitin mediated proteolysis
CC when not protected by its association to the kinetochore. This may
CC ensure exclusive localization of CSE4 to the kinetochore (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H3 family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28135.1; -; Genomic_DNA.
DR RefSeq; XP_710644.1; XM_705552.2.
DR AlphaFoldDB; Q59LN9; -.
DR SMR; Q59LN9; -.
DR STRING; 237561.Q59LN9; -.
DR PRIDE; Q59LN9; -.
DR GeneID; 3647750; -.
DR KEGG; cal:CAALFM_C300860WA; -.
DR CGD; CAL0000183421; CSE4.
DR VEuPathDB; FungiDB:C3_00860W_A; -.
DR eggNOG; KOG1745; Eukaryota.
DR HOGENOM; CLU_078295_3_0_1; -.
DR InParanoid; Q59LN9; -.
DR OMA; WQSHAIM; -.
DR OrthoDB; 1564596at2759; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0043505; C:CENP-A containing nucleosome; IDA:CGD.
DR GO; GO:0000775; C:chromosome, centromeric region; IDA:CGD.
DR GO; GO:0000776; C:kinetochore; IDA:CGD.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019237; F:centromeric DNA binding; IDA:CGD.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:CGD.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000164; Histone_H3/CENP-A.
DR PANTHER; PTHR11426; PTHR11426; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00622; HISTONEH3.
DR SMART; SM00428; H3; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00959; HISTONE_H3_2; 1.
PE 3: Inferred from homology;
KW Centromere; Chromosome; DNA-binding; Kinetochore; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..211
FT /note="Histone H3-like centromeric protein CSE4"
FT /id="PRO_0000270596"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..207
FT /note="H3-like"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 24442 MW; F75C3987B2EE29F2 CRC64;
MARLSGQSSG RQTGQGTSAE AIRQQREELR RQRELRLQQQ QQAERQQQRQ QYRTEQSPIV
PAATSSSRYS QFGIYRNQPG DVVDTLASSL PRRTTTTRPE VNRTVPRVKK RYRPGTKALR
EIRQYQKSTD LLIRKLPFAR LVREISLDFV GPSYGLRWQS NAILALQEAS ESFLIHLLED
TNLCAIHAKR VTIMQKDIQL ARRIRGQSWI L