ID   CENPA_CANGA             Reviewed;         240 AA.
AC   Q874J6; Q6FIM9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Histone H3-like centromeric protein CSE4;
DE   AltName: Full=CENP-A homolog;
GN   Name=CSE4; OrderedLocusNames=CAGL0M13145g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15470243; DOI=10.1128/ec.3.5.1154-1163.2004;
RA   Stoyan T., Carbon J.;
RT   "Inner kinetochore of the pathogenic yeast Candida glabrata.";
RL   Eukaryot. Cell 3:1154-1163(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histone H3-like variant which exclusively replaces
CC       conventional H3 in the nucleosome core of centromeric chromatin at the
CC       inner plate of the kinetochore. Required for recruitment and assembly
CC       of kinetochore proteins, mitotic progression and chromosome
CC       segregation. May serve as an epigenetic mark that propagates centromere
CC       identity through replication and cell division (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the core kinetochore. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC       Note=Localizes exclusively in the kinetochore domain of centromeres.
CC       {ECO:0000250}.
CC   -!- PTM: Ubiquitinated. Is degraded through ubiquitin mediated proteolysis
CC       when not protected by its association to the kinetochore. This may
CC       ensure exclusive localization of CSE4 to the kinetochore (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY230411; AAO73467.1; -; Genomic_DNA.
DR   EMBL; CR380959; CAG62895.1; -; Genomic_DNA.
DR   RefSeq; XP_449915.1; XM_449915.1.
DR   AlphaFoldDB; Q874J6; -.
DR   SMR; Q874J6; -.
DR   STRING; 5478.XP_449915.1; -.
DR   EnsemblFungi; CAG62895; CAG62895; CAGL0M13145g.
DR   GeneID; 2891205; -.
DR   KEGG; cgr:CAGL0M13145g; -.
DR   CGD; CAL0137371; CSE4.
DR   VEuPathDB; FungiDB:CAGL0M13145g; -.
DR   eggNOG; KOG1745; Eukaryota.
DR   HOGENOM; CLU_078295_3_0_1; -.
DR   InParanoid; Q874J6; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005729; C:2-micrometer circle DNA; IEA:EnsemblFungi.
DR   GO; GO:0043505; C:CENP-A containing nucleosome; IEA:EnsemblFungi.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019237; F:centromeric DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030543; P:2-micrometer plasmid partitioning; IEA:EnsemblFungi.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:EnsemblFungi.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IEA:EnsemblFungi.
DR   GO; GO:0061644; P:protein localization to CENP-A containing chromatin; IEA:EnsemblFungi.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000164; Histone_H3/CENP-A.
DR   PANTHER; PTHR11426; PTHR11426; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00622; HISTONEH3.
DR   SMART; SM00428; H3; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Centromere; Chromosome; DNA-binding; Kinetochore; Nucleus;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..240
FT                   /note="Histone H3-like centromeric protein CSE4"
FT                   /id="PRO_0000270597"
FT   REGION          83..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..238
FT                   /note="H3-like"
SQ   SEQUENCE   240 AA;  28186 MW;  3ED58B7CF99BDAF9 CRC64;
     MSTRQAVFER DVDEDRWPRS ARGLAGVNTV FEGDSEINSK AMRLLEKTRH RRNLLNRRED
     RRRYLGGVKA KAIESDYYHR NQLPSSYDAG NDDFEPINNS HVESEEENKR LPEKYSLDKY
     VKRSRKQRDH RHIVAKPKEK RNFAPSKLAM YEIEKYQRST ALLIQKIPFA KLVKEVTEEF
     AGESQDLRWQ SMAILALQEA SEAYLVGLLE HTNLLALHAK RITIMKKDMQ LARRIRGQFI