ID   CENPA_YARLI             Reviewed;         150 AA.
AC   Q6CER9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Histone H3-like centromeric protein CSE4;
DE   AltName: Full=CENP-A homolog;
GN   Name=CSE4; OrderedLocusNames=YALI0B13508g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histone H3-like variant which exclusively replaces
CC       conventional H3 in the nucleosome core of centromeric chromatin at the
CC       inner plate of the kinetochore. Required for recruitment and assembly
CC       of kinetochore proteins, mitotic progression and chromosome
CC       segregation. May serve as an epigenetic mark that propagates centromere
CC       identity through replication and cell division (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the core kinetochore. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC       Note=Localizes exclusively in the kinetochore domain of centromeres.
CC       {ECO:0000250}.
CC   -!- PTM: Ubiquitinated. Is degraded through ubiquitin mediated proteolysis
CC       when not protected by its association to the kinetochore. This may
CC       ensure exclusive localization of CSE4 to the kinetochore (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H3 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG83094.1; -; Genomic_DNA.
DR   RefSeq; XP_500843.1; XM_500843.1.
DR   AlphaFoldDB; Q6CER9; -.
DR   SMR; Q6CER9; -.
DR   STRING; 4952.CAG83094; -.
DR   EnsemblFungi; CAG83094; CAG83094; YALI0_B13508g.
DR   GeneID; 2907440; -.
DR   KEGG; yli:YALI0B13508g; -.
DR   VEuPathDB; FungiDB:YALI0_B13508g; -.
DR   HOGENOM; CLU_078295_3_3_1; -.
DR   InParanoid; Q6CER9; -.
DR   OMA; MTDTIDY; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005729; C:2-micrometer circle DNA; IEA:EnsemblFungi.
DR   GO; GO:0043505; C:CENP-A containing nucleosome; IEA:EnsemblFungi.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019237; F:centromeric DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030543; P:2-micrometer plasmid partitioning; IEA:EnsemblFungi.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:EnsemblFungi.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IEA:EnsemblFungi.
DR   GO; GO:0061644; P:protein localization to CENP-A containing chromatin; IEA:EnsemblFungi.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000164; Histone_H3/CENP-A.
DR   PANTHER; PTHR11426; PTHR11426; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00622; HISTONEH3.
DR   SMART; SM00428; H3; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Centromere; Chromosome; DNA-binding; Kinetochore; Nucleus;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..150
FT                   /note="Histone H3-like centromeric protein CSE4"
FT                   /id="PRO_0000297756"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          32..145
FT                   /note="H3-like"
FT   COMPBIAS        31..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   150 AA;  16550 MW;  B4A0811CA7230432 CRC64;
     MARISLASSS AGVAGKPRGG GGLHPLGQTR KTLPGERRDT TQKITKPRYK PGQKALKEIR
     RYQRGTELLI AKLPFARVVR EVALNYLGSE YGNLQWQSMA LLALQEAAEA FLVHLFEDVN
     LCAIHAKRVT IMQKDMQLAR RIRGAWGGAG