ID   CENPH_BOVIN             Reviewed;         244 AA.
AC   Q3T0L1;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Centromere protein H;
DE            Short=CENP-H;
GN   Name=CENPH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a
CC       complex that plays a central role in assembly of kinetochore proteins,
CC       mitotic progression and chromosome segregation. The CENPA-NAC complex
CC       recruits the CENPA-CAD (nucleosome distal) complex and may be involved
CC       in incorporation of newly synthesized CENPA into centromeres (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Component of the CENPA-NAC complex, at least
CC       composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The
CC       CENPA-NAC complex interacts with the CENPA-CAD complex, composed of
CC       CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts
CC       with KIF2C and NDC80 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Associates with active centromere-kinetochore
CC       complexes throughout the cell cycle. Colocalizes with inner kinetochore
CC       plate proteins CENPA and CENPC during both interphase and metaphase (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-H/MCM16 family. {ECO:0000255}.
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DR   EMBL; BC102350; AAI02351.1; -; mRNA.
DR   RefSeq; NP_001029408.1; NM_001034236.2.
DR   AlphaFoldDB; Q3T0L1; -.
DR   SMR; Q3T0L1; -.
DR   STRING; 9913.ENSBTAP00000036669; -.
DR   PaxDb; Q3T0L1; -.
DR   PRIDE; Q3T0L1; -.
DR   Ensembl; ENSBTAT00000036817; ENSBTAP00000036669; ENSBTAG00000014246.
DR   GeneID; 505284; -.
DR   KEGG; bta:505284; -.
DR   CTD; 64946; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014246; -.
DR   VGNC; VGNC:27177; CENPH.
DR   eggNOG; ENOG502S0VG; Eukaryota.
DR   GeneTree; ENSGT00390000009578; -.
DR   HOGENOM; CLU_097390_0_0_1; -.
DR   InParanoid; Q3T0L1; -.
DR   OMA; KSHQESW; -.
DR   OrthoDB; 1467214at2759; -.
DR   TreeFam; TF101134; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000014246; Expressed in oocyte and 97 other tissues.
DR   ExpressionAtlas; Q3T0L1; baseline.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043515; F:kinetochore binding; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   InterPro; IPR040034; CENP-H.
DR   InterPro; IPR008426; CENP-H_C.
DR   PANTHER; PTHR48122; PTHR48122; 1.
DR   Pfam; PF05837; CENP-H; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Centromere; Chromosome; Coiled coil; Isopeptide bond;
KW   Kinetochore; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.
FT   CHAIN           1..244
FT                   /note="Centromere protein H"
FT                   /id="PRO_0000240135"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          66..104
FT                   /evidence="ECO:0000255"
FT   COILED          146..189
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3R5"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3R5"
FT   MOD_RES         65
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3R5"
FT   CROSSLNK        64
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3R5"
SQ   SEQUENCE   244 AA;  28064 MW;  F95BADD08D67A2B2 CRC64;
     METQSEEQAV TKPADSGGEG GPPQVAGAQA ARPEDRMTLL LRLRAQTKQQ LLEYKSMVDA
     NEEKTPEQIM QEKQIEAKIE ELENEVEEAK TAFEMKKLAL DRMQLSTALK KHLEKVDIKT
     SVLMDNMKQI LNLNKLIMKS QQETWDLEEK LLDVRKKRLQ LKQASERKLL EIQTEKNKQK
     DDLDSMENSD KIKAIQQNLE TEIQITTVIQ HVFQNLILGS KVNWAEDPAL KETVLQLEKN
     LTMI